| Reaction Details |
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 | Report a problem with these data |
| Target | Prostacyclin synthase |
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| Ligand | BDBM50036361 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_158020 (CHEMBL768446) |
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| IC50 | 12000±n/a nM |
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| Citation |  Faull, AW; Brewster, AG; Brown, GR; Smithers, MJ; Jackson, R Dual-acting thromboxane receptor antagonist/synthase inhibitors: synthesis and biological properties of [2-substituted-4-(3-pyridyl)-1,3-dioxan-5-yl] alkenoic acids. J Med Chem38:686-94 (1995) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostacyclin synthase |
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| Name: | Prostacyclin synthase |
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| Synonyms: | CYP8 | CYP8A1 | PTGIS | PTGIS_HUMAN | Prostaglandin I2 synthase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 57109.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_157785 |
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| Residue: | 500 |
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| Sequence: | MAWAALLGLLAALLLLLLLSRRRTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEK
HGDIFTILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDE
KARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTL
YGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKL
LSPARLARRAHRSKWLESYLLHLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLL
KNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITRE
VVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDF
YKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSR
YGFGLMQPEHDVPVRYRIRP
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| BDBM50036361 |
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| n/a |
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| Name | BDBM50036361 |
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| Synonyms: | (Z)-6-{2-[1-(2-Cyano-4-methyl-phenoxy)-1-methyl-ethyl]-4-pyridin-3-yl-[1,3]dioxan-5-yl}-hex-4-enoic acid | CHEMBL445644 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H30N2O5 |
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| Mol. Mass. | 450.5268 |
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| SMILES | Cc1ccc(OC(C)(C)C2OCC(C\C=C/CCC(O)=O)C(O2)c2cccnc2)c(c1)C#N |
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| Structure | 
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