Reaction Details |
| Report a problem with these data |
Target | Prostacyclin synthase |
---|
Ligand | BDBM50036378 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_158020 (CHEMBL768446) |
---|
IC50 | >100000±n/a nM |
---|
Citation | Faull, AW; Brewster, AG; Brown, GR; Smithers, MJ; Jackson, R Dual-acting thromboxane receptor antagonist/synthase inhibitors: synthesis and biological properties of [2-substituted-4-(3-pyridyl)-1,3-dioxan-5-yl] alkenoic acids. J Med Chem38:686-94 (1995) [PubMed] |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Prostacyclin synthase |
---|
Name: | Prostacyclin synthase |
Synonyms: | CYP8 | CYP8A1 | PTGIS | PTGIS_HUMAN | Prostaglandin I2 synthase |
Type: | PROTEIN |
Mol. Mass.: | 57109.87 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_157785 |
Residue: | 500 |
Sequence: | MAWAALLGLLAALLLLLLLSRRRTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEK
HGDIFTILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDE
KARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTL
YGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKL
LSPARLARRAHRSKWLESYLLHLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLL
KNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITRE
VVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDF
YKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSR
YGFGLMQPEHDVPVRYRIRP
|
|
|
BDBM50036378 |
---|
n/a |
---|
Name | BDBM50036378 |
Synonyms: | (Z)-6-{2-[1-(2-Cyano-5-methyl-phenoxy)-1-methyl-ethyl]-4-pyridin-3-yl-[1,3]dioxan-5-yl}-hex-4-enoic acid | CHEMBL350816 |
Type | Small organic molecule |
Emp. Form. | C26H30N2O5 |
Mol. Mass. | 450.5268 |
SMILES | Cc1ccc(C#N)c(OC(C)(C)C2OCC(C\C=C/CCC(O)=O)C(O2)c2cccnc2)c1 |
Structure |
|