| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 2B |
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| Ligand | BDBM50492221 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_968360 (CHEMBL2400231) |
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| Ki | 13±n/a nM |
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| Citation |  Zhao, G; Kwon, C; Bisaha, SN; Stein, PD; Rossi, KA; Cao, X; Ung, T; Wu, G; Hung, CP; Malmstrom, SE; Zhang, G; Qu, Q; Gan, J; Keim, WJ; Cullen, MJ; Rohrbach, KW; Devenny, J; Pelleymounter, MA; Miller, KJ; Robl, JA Synthesis and SAR of potent and selective tetrahydropyrazinoisoquinolinone 5-HT(2C) receptor agonists. Bioorg Med Chem Lett23:3914-9 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 2B |
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| Name: | 5-hydroxytryptamine receptor 2B |
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| Synonyms: | 5-HT-2B | 5-HT2B | 5-hydroxytryptamine (serotonin) receptor 2B [Homo sapiens] | 5-hydroxytryptamine receptor 2B (5-HT2B) | 5-hydroxytryptamine receptor 2C (5HT2C) | 5HT2B_HUMAN | HTR2B | Serotonin (5-HT3) receptor | Serotonin 2b (5-HT2b) receptor | Serotonin Receptor 2B |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 54312.47 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Receptor binding assays were performed using human clone stably expressed in CHO cells. |
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| Residue: | 481 |
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| Sequence: | MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALL
ILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAM
WPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVW
LISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLT
IHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDET
LMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQM
LLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNP
MAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSY
V
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| BDBM50492221 |
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| n/a |
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| Name | BDBM50492221 |
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| Synonyms: | CHEMBL2397889 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H16N2O |
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| Mol. Mass. | 216.2789 |
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| SMILES | [H][C@@]12CNCCN1C(=O)c1c(C)cccc1C2 |r| |
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| Structure | 
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