| Reaction Details |
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 | Report a problem with these data |
| Target | Type-2 angiotensin II receptor |
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| Ligand | BDBM50039913 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_36763 (CHEMBL651250) |
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| IC50 | 170±n/a nM |
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| Citation |  Ashton, WT; Chang, LL; Flanagan, KL; Hutchins, SM; Naylor, EM; Chakravarty, PK; Patchett, AA; Greenlee, WJ; Chen, TB; Faust, KA Triazolinone biphenylsulfonamide derivatives as orally active angiotensin II antagonists with potent AT1 receptor affinity and enhanced AT2 affinity. J Med Chem37:2808-24 (1994) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Type-2 angiotensin II receptor |
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| Name: | Type-2 angiotensin II receptor |
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| Synonyms: | AGTR2_RAT | AT2 | Agtr2 | Angiotensin II AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Type-2 angiotensin II receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 41346.62 |
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| Organism: | RAT |
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| Description: | Angiotensin II AT2 0 0::P35351 |
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| Residue: | 363 |
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| Sequence: | MKDNFSFAATSRNITSSLPFDNLNATGTNESAFNCSHKPADKHLEAIPVLYYMIFVIGFA
VNIVVVSLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVF
GSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYVVPLVWCMACLSSLPTFY
FRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLK
TNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALTWMGIINSCEVIAVIDLAL
PFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRETMSCRKSSSLREMDT
FVS
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| BDBM50039913 |
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| n/a |
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| Name | BDBM50039913 |
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| Synonyms: | 4'-[3-Butyl-5-oxo-1-(2-trifluoromethyl-phenyl)-1,5-dihydro-[1,2,4]triazol-4-ylmethyl]-biphenyl-2-sulfonic acid (5-bromo-furan-2-carbonyl)-amide | CHEMBL327191 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H26BrF3N4O5S |
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| Mol. Mass. | 703.526 |
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| SMILES | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)c1ccc(Br)o1 |
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| Structure | 
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