Reaction Details |
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Target | Histamine H3 receptor |
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Ligand | BDBM50494142 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_990483 (CHEMBL2446560) |
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IC50 | 79±n/a nM |
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Citation | Harusawa, S; Sawada, K; Magata, T; Yoneyama, H; Araki, L; Usami, Y; Hatano, K; Yamamoto, K; Yamamoto, D; Yamatodani, A Synthesis and evaluation of N-alkyl-S-[3-(piperidin-1-yl)propyl]isothioureas: high affinity and human/rat species-selective histamine H(3) receptor antagonists. Bioorg Med Chem Lett23:6415-20 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histamine H3 receptor |
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Name: | Histamine H3 receptor |
Synonyms: | G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4) |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 48691.47 |
Organism: | Homo sapiens (Human) |
Description: | Binding assays were using CHO cells stably expressing hH3R receptors. |
Residue: | 445 |
Sequence: | MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS
SAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAA
GPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSV
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSL
AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR
RAFTKLLCPQKLKIQPHSSLEHCWK
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BDBM50494142 |
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n/a |
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Name | BDBM50494142 |
Synonyms: | CHEMBL2441935 |
Type | Small organic molecule |
Emp. Form. | C16H25Cl2N3S |
Mol. Mass. | 362.361 |
SMILES | Cl.Clc1ccc(CNC(=N)SCCCN2CCCCC2)cc1 |
Structure |
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