Ki Summary

Reaction Details

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Target

Matrix protein 2 [1-96]

Ligand

BDBM50494444

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1275613 (CHEMBL3090744)

IC50

13800±n/a nM

Citation

Rey-Carrizo, M; Torres, E; Ma, C; Barniol-Xicota, M; Wang, J; Wu, Y; Naesens, L; DeGrado, WF; Lamb, RA; Pinto, LH; V�zquez, S 3-Azatetracyclo[5.2.1.1(5,8).0(1,5)]undecane derivatives: from wild-type inhibitors of the M2 ion channel of influenza A virus to derivatives with potent activity against the V27A mutant. J Med Chem56:9265-74 (2013) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Matrix protein 2 [1-96]

Name:

Matrix protein 2 [1-96]

Synonyms:

M | M2_I72A2 | Matrix protein 2

Type:

PROTEIN

Mol. Mass.:

11051.96

Organism:

Influenza A virus

Description:

ChEMBL_1453980

Residue:

Sequence:

MSLLTEVETPIRNEWGCRCNDSSDPLVVAASIIGILHLILWILDRLFFKCIYRFFEHGLK
RGPSTEGVPESMREEYRKEQQSAVDADDSHFVSIEL

BDBM50494444

n/a

Name

BDBM50494444

Synonyms:

CHEMBL3088168

Type

Small organic molecule

Emp. Form.

C15H26ClN3

Mol. Mass.

283.84

SMILES

Cl.CCC12CC34CN(CC3(C1)CC2(CC)C4)C(N)=N |TLB:13:12:4:9.10,10:9:15:3.4,THB:11:9:4:15.12,11:12:4:9.10,8:9:4:15.12,(38.18,-45.8,;33.92,-47.33,;33.78,-48.86,;35.04,-49.75,;37.06,-50.27,;37.11,-51.7,;38.53,-52.05,;39.28,-50.16,;37.94,-51,;36.64,-50.72,;36.36,-49.5,;35.84,-52.07,;34.54,-51.5,;33,-51.46,;32.26,-50.11,;36.14,-52.75,;40.64,-49.37,;41.98,-50.14,;40.64,-47.83,)|

Structure