| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50041937 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_53935 (CHEMBL667768) |
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| IC50 | 19000±n/a nM |
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| Citation |  Rosowsky, A; Mota, CE; Wright, JE; Freisheim, JH; Heusner, JJ; McCormack, JJ; Queener, SF 2,4-Diaminothieno[2,3-d]pyrimidine analogues of trimetrexate and piritrexim as potential inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase. J Med Chem36:3103-12 (1993) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DYR_LACCA | dhfR | folA |
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| Type: | PROTEIN |
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| Mol. Mass.: | 18437.08 |
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| Organism: | Lactobacillus casei |
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| Description: | ChEMBL_1357878 |
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| Residue: | 163 |
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| Sequence: | MTAFLWAQDRDGLIGKDGHLPWHLPDDLHYFRAQTVGKIMVVGRRTYESFPKRPLPERTN
VVLTHQEDYQAQGAVVVHDVAAVFAYAKQHPDQELVIAGGAQIFTAFKDDVDTLLVTRLA
GSFEGDTKMIPLNWDDFTKVSSRTVEDTNPALTHTYEVWQKKA
|
|
|
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| BDBM50041937 |
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| n/a |
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| Name | BDBM50041937 |
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| Synonyms: | 5-Benzyl-6-methyl-thieno[2,3-d]pyrimidine-2,4-diamine | CHEMBL321826 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H14N4S |
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| Mol. Mass. | 270.353 |
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| SMILES | Cc1sc2nc(N)nc(N)c2c1Cc1ccccc1 |
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| Structure | 
|
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