| Reaction Details |
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 | Report a problem with these data |
| Target | Type-2 angiotensin II receptor |
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| Ligand | BDBM50043450 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_35406 (CHEMBL647505) |
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| IC50 | 2700±n/a nM |
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| Citation |  Dhanoa, DS; Bagley, SW; Chang, RS; Lotti, VJ; Chen, TB; Kivlighn, SD; Zingaro, GJ; Siegl, PK; Patchett, AA; Greenlee, WJ Non-peptide angiotensin II receptor antagonists. 1. Design, synthesis, and biological activity of N-substituted indoles and dihydroindoles. J Med Chem36:4230-8 (1994) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Type-2 angiotensin II receptor |
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| Name: | Type-2 angiotensin II receptor |
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| Synonyms: | AGTR2_RAT | AT2 | Agtr2 | Angiotensin II AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Type-2 angiotensin II receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 41346.62 |
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| Organism: | RAT |
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| Description: | Angiotensin II AT2 0 0::P35351 |
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| Residue: | 363 |
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| Sequence: | MKDNFSFAATSRNITSSLPFDNLNATGTNESAFNCSHKPADKHLEAIPVLYYMIFVIGFA
VNIVVVSLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVF
GSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYVVPLVWCMACLSSLPTFY
FRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLK
TNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALTWMGIINSCEVIAVIDLAL
PFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRETMSCRKSSSLREMDT
FVS
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|
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| BDBM50043450 |
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| n/a |
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| Name | BDBM50043450 |
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| Synonyms: | 3,6-Dichloro-2-[5-(2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-4-ylmethyl)-indole-1-carbonyl]-benzoic acid | CHEMBL337086 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H22Cl2N4O3 |
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| Mol. Mass. | 521.395 |
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| SMILES | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2n(ccc2c1)C(=O)c1c(Cl)ccc(Cl)c1C(O)=O |
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| Structure | 
|
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