Ki Summary

Reaction Details

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Target

Mas-related G-protein coupled receptor member X1

Ligand

BDBM50497465

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1436307 (CHEMBL3388388)

IC50

800±n/a nM

Citation

Hin, N; Alt, J; Zimmermann, SC; Delahanty, G; Ferraris, DV; Rojas, C; Li, F; Liu, Q; Dong, X; Slusher, BS; Tsukamoto, T Peptidomimetics of Arg-Phe-NH2 as small molecule agonists of Mas-related gene C (MrgC) receptors. Bioorg Med Chem22:5831-7 (2014) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Mas-related G-protein coupled receptor member X1

Name:

Mas-related G-protein coupled receptor member X1

Synonyms:

MRGPRX1 | MRGX1 | MRGX1_HUMAN | SNSR3 | SNSR4

Type:

PROTEIN

Mol. Mass.:

36253.68

Organism:

Homo sapiens (Human)

Description:

ChEMBL_516621

Residue:

322

Sequence:

MDPTISTLDTELTPINGTEETLCYKQTLSLTVLTCIVSLVGLTGNAVVLWLLGCRMRRNA
FSIYILNLAAADFLFLSGRLIYSLLSFISIPHTISKILYPVMMFSYFAGLSFLSAVSTER
CLSVLWPIWYRCHRPTHLSAVVCVLLWALSLLRSILEWMLCGFLFSGADSAWCQTSDFIT
VAWLIFLCVVLCGSSLVLLIRILCGSRKIPLTRLYVTILLTVLVFLLCGLPFGIQFFLFL
WIHVDREVLFCHVHLVSIFLSALNSSANPIIYFFVGSFRQRQNRQNLKLVLQRALQDASE
VDEGGGQLPEEILELSGSRLEQ

BDBM50497465

n/a

Name

BDBM50497465

Synonyms:

CHEMBL3343995

Type

Small organic molecule

Emp. Form.

C29H29NO2

Mol. Mass.

423.5461

SMILES

COc1ccccc1C(=O)\C=C1/C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 |(10.52,-16.71,;11.85,-17.48,;13.18,-16.72,;14.51,-17.49,;15.85,-16.72,;15.85,-15.17,;14.52,-14.41,;13.19,-15.18,;11.86,-14.41,;10.52,-15.17,;11.86,-12.87,;10.53,-12.09,;9.2,-12.86,;7.87,-12.09,;7.87,-10.55,;9.2,-9.78,;9.96,-11.11,;8.42,-11.1,;10.53,-10.55,;11.87,-9.79,;11.87,-8.25,;13.21,-7.49,;13.21,-5.95,;11.88,-5.17,;10.54,-5.95,;10.54,-7.48,;13.2,-10.56,;13.19,-12.1,;14.52,-12.88,;15.86,-12.11,;15.86,-10.56,;14.53,-9.8,)|

Structure