Reaction Details |
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Target | Mu-type opioid receptor |
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Ligand | BDBM50045742 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_222070 (CHEMBL843461) |
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Ki | 0.260000±n/a nM |
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Citation | Zimmerman, DM; Leander, JD; Cantrell, BE; Reel, JK; Snoddy, J; Mendelsohn, LG; Johnson, BG; Mitch, CH Structure-activity relationships of trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine antagonists for mu- and kappa-opioid receptors. J Med Chem36:2833-41 (1993) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Mu-type opioid receptor |
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Name: | Mu-type opioid receptor |
Synonyms: | MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 44503.11 |
Organism: | Rattus norvegicus (rat) |
Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor. |
Residue: | 398 |
Sequence: | MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQT
GSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST
LPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRT
PRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFA
FIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYV
IIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQ
QNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
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BDBM50045742 |
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n/a |
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Name | BDBM50045742 |
Synonyms: | 3-[3,4-Dimethyl-1-(3-thiophen-3-yl-propyl)-piperidin-4-yl]-phenol | CHEMBL317097 |
Type | Small organic molecule |
Emp. Form. | C20H27NOS |
Mol. Mass. | 329.499 |
SMILES | C[C@H]1CN(CCCc2ccsc2)CC[C@@]1(C)c1cccc(O)c1 |
Structure |
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