| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Elastase |
|---|
| Ligand | BDBM50241254 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1442820 (CHEMBL3376525) |
|---|
| IC50 | 400±n/a nM |
|---|
| Citation |  Adekoya, OA; Sjøli, S; Wuxiuer, Y; Bilto, I; Marques, SM; Santos, MA; Nuti, E; Cercignani, G; Rossello, A; Winberg, JO; Sylte, I Inhibition of pseudolysin and thermolysin by hydroxamate-based MMP inhibitors. Eur J Med Chem89:340-8 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Elastase |
|---|
| Name: | Elastase |
|---|
| Synonyms: | ELAS_PSEAE | Pseudolysin | lasB |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 53687.94 |
|---|
| Organism: | Pseudomonas aeruginosa |
|---|
| Description: | ChEMBL_619859 |
|---|
| Residue: | 498 |
|---|
| Sequence: | MKKVSTLDLLFVAIMGVSPAAFAADLIDVSKLPSKAAQGAPGPVTLQAAVGAGGADELKA
IRSTTLPNGKQVTRYEQFHNGVRVVGEAITEVKGPGKSVAAQRSGHFVANIAADLPGSTT
AAVSAEQVLAQAKSLKAQGRKTENDKVELVIRLGENNIAQLVYNVSYLIPGEGLSRPHFV
IDAKTGEVLDQWEGLAHAEAGGPGGNQKIGKYTYGSDYGPLIVNDRCEMDDGNVITVDMN
SSTDDSKTTPFRFACPTNTYKQVNGAYSPLNDAHFFGGVVFKLYRDWFGTSPLTHKLYMK
VHYGRSVENAYWDGTAMLFGDGATMFYPLVSLDVAAHEVSHGFTEQNSGLIYRGQSGGMN
EAFSDMAGEAAEFYMRGKNDFLIGYDIKKGSGALRYMDQPSRDGRSIDNASQYYNGIDVH
HSSGVYNRAFYLLANSPGWDTRKAFEVFVDANRYYWTATSNYNSGACGVIRSAQNRNYSA
ADVTRAFSTVGVTCPSAL
|
|
|
|---|
| BDBM50241254 |
|---|
| n/a |
|---|
| Name | BDBM50241254 |
|---|
| Synonyms: | 2-(benzyl-hydroxycarbamoylmethyl-amino)-N-[2-(4-sulfamoyl-phenyl)-ethyl]-acetamide | CHEMBL234737 | N-Benzyl-N-{[2-(4-sulfamoylphenyl)ethylcarbamoyl]methyl}-aminoacetohydroxamic Acid |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H24N4O5S |
|---|
| Mol. Mass. | 420.483 |
|---|
| SMILES | NS(=O)(=O)c1ccc(CCNC(=O)CN(CC(=O)NO)Cc2ccccc2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
