| Reaction Details |
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 | Report a problem with these data |
| Target | Thymidylate kinase |
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| Ligand | BDBM50498055 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1461346 (CHEMBL3396196) |
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| IC50 | 3600±n/a nM |
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| Citation |  Naik, M; Raichurkar, A; Bandodkar, BS; Varun, BV; Bhat, S; Kalkhambkar, R; Murugan, K; Menon, R; Bhat, J; Paul, B; Iyer, H; Hussein, S; Tucker, JA; Vogtherr, M; Embrey, KJ; McMiken, H; Prasad, S; Gill, A; Ugarkar, BG; Venkatraman, J; Read, J; Panda, M Structure guided lead generation for M. tuberculosis thymidylate kinase (Mtb TMK): discovery of 3-cyanopyridone and 1,6-naphthyridin-2-one as potent inhibitors. J Med Chem58:753-66 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thymidylate kinase |
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| Name: | Thymidylate kinase |
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| Synonyms: | KTHY_MYCTU | TMPK | Thymidine monophosphate kinase | dTMP kinase | tmk |
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| Type: | PROTEIN |
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| Mol. Mass.: | 22636.29 |
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| Organism: | Mycobacterium tuberculosis |
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| Description: | ChEMBL_208218 |
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| Residue: | 214 |
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| Sequence: | MLIAIEGVDGAGKRTLVEKLSGAFRAAGRSVATLAFPRYGQSVAADIAAEALHGEHGDLA
SSVYAMATLFALDRAGAVHTIQGLCRGYDVVILDRYVASNAAYSAARLHENAAGKAAAWV
QRIEFARLGLPKPDWQVLLAVSAELAGERSRGRAQRDPGRARDNYERDAELQQRTGAVYA
ELAAQGWGGRWLVVGADVDPGRLAATLAPPDVPS
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|
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| BDBM50498055 |
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| n/a |
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| Name | BDBM50498055 |
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| Synonyms: | CHEMBL3394145 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H8N2OS2 |
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| Mol. Mass. | 248.324 |
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| SMILES | CSc1cc([nH]c(=O)c1C#N)-c1cccs1 |
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| Structure | 
|
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