| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Lysine-specific demethylase 4E |
|---|
| Ligand | BDBM50498673 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1519859 (CHEMBL3624702) |
|---|
| IC50 | 398±n/a nM |
|---|
| Citation |  England, KS; Tumber, A; Krojer, T; Scozzafava, G; Ng, SS; Daniel, M; Szykowska, A; Che, K; von Delft, F; Burgess-Brown, NA; Kawamura, A; Schofield, CJ; Brennan, PE Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor. Medchemcomm5:1879-1886 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Lysine-specific demethylase 4E |
|---|
| Name: | Lysine-specific demethylase 4E |
|---|
| Synonyms: | 2-OG-Dependent Histone Demethylase JMJD2E | Histone Lysine Demethylase | Jumonji domain-containing protein 2E (JMJD2E) | KDM4D-like protein | KDM4DL | KDM4E | KDM4E_HUMAN | Lysine-specific demethylase 4D-like | Lysine-specific demethylase 4E | Lysine-specific demethylase 4E (KDM4E) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 56815.71 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | B2RXH2 |
|---|
| Residue: | 506 |
|---|
| Sequence: | MKSVHSSPQNTSHTIMTFYPTMEEFADFNTYVAYMESQGAHQAGLAKVIPPKEWKARQMY
DDIEDILIATPLQQVTSGQGGVFTQYHKKKKAMRVGQYRRLANSKKYQTPPHQNFADLEQ
RYWKSHPGNPPIYGADISGSLFEESTKQWNLGHLGTILDLLEQECGVVIEGVNTPYLYFG
MWKTTFAWHTEDMDLYSINYLHFGEPKTWYVVPPEHGQHLERLARELFPDISRGCEAFLR
HKVALISPTVLKENGIPFNCMTQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRWIDY
GKMASQCSCGESTVTFSMDPFVRIVQPESYELWKHRQDLAIVEHTEPRVAESQELSNWRD
DIVLRRAALGLRLLPNLTAQCPTQPVSSGHCYNPKGCGTDAVPGSAFQSSAYHTQTQSLT
LGMSARVLLPSTGSWGSGRGRGRGQGQGRGCSRGRGHGCCTRELGTEEPTVQPASKRRLL
MGTRSRAQGHRPQLPLANDLMTNLSL
|
|
|
|---|
| BDBM50498673 |
|---|
| n/a |
|---|
| Name | BDBM50498673 |
|---|
| Synonyms: | CHEMBL3621852 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C11H8N2O2 |
|---|
| Mol. Mass. | 200.1934 |
|---|
| SMILES | OC(=O)c1ccnc(c1)-c1ccccn1 |
|---|
| Structure | 
|
|---|
Search and Browse
