Reaction Details |
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Target | Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha |
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Ligand | BDBM50498800 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1518712 (CHEMBL3625035) |
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IC50 | 690±n/a nM |
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Citation | Kwon, DY; Lee, HE; Weitzel, DH; Park, K; Lee, SH; Lee, CT; Stephenson, TN; Park, H; Fitzgerald, MC; Chi, JT; Mook, RA; Dewhirst, MW; Lee, YM; Hong, J Synthesis and Biological Evaluation of Manassantin Analogues for Hypoxia-Inducible Factor 1? Inhibition. J Med Chem58:7659-71 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha |
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Name: | Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha |
Synonyms: | Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of ChEMBL is 799337 |
Components: | This complex has 2 components. |
Component 1 |
Name: | Hypoxia-inducible factor 1-alpha |
Synonyms: | BHLHE78 | HIF-1-alpha | HIF-1-alpha, HIF-2-alpha | HIF1A | HIF1A_HUMAN | Hypoxia inducible factors | Hypoxia-inducible factor 1 alpha | Hypoxia-inducible factor 1-alpha | MOP1 | PASD8 | von Hippel-Lindau disease tumor suppressor/Elongin-C/Elongin-B/HIF1A |
Type: | Protein |
Mol. Mass.: | 92647.24 |
Organism: | Homo sapiens (Human) |
Description: | Q16665 |
Residue: | 826 |
Sequence: | MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVM
RLTISYLRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYM
GLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGR
TMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSK
TFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQV
TTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECV
LKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTET
DDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEP
NPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLF
AEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVT
VFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYR
DTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRTTVPEEELNPKILALQNAQRKR
KMEHDGSLFQAVGIGTLLQQPDDHAATTSLSWKRVKGCKSSEQNGMEQKTIILIPSDLAC
RLLGQSMDESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN
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Component 2 |
Name: | Endothelial PAS domain-containing protein 1 |
Synonyms: | BHLHE73 | EPAS1 | EPAS1_HUMAN | HIF2A | MOP2 | PASD2 | endothelial PAS domain-containing protein 1 |
Type: | PROTEIN |
Mol. Mass.: | 96453.58 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1506501 |
Residue: | 870 |
Sequence: | MTADKEKKRSSSERRKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLA
ISFLRTHKLLSSVCSENESEAEADQQMDNLYLKALEGFIAVVTQDGDMIFLSENISKFMG
LTQVELTGHSIFDFTHPCDHEEIRENLSLKNGSGFGKKSKDMSTERDFFMRMKCTVTNRG
RTVNLKSATWKVLHCTGQVKVYNNCPPHNSLCGYKEPLLSCLIIMCEPIQHPSHMDIPLD
SKTFLSRHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLCTKG
QVVSGQYRMLAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNYVLSEIEKNDVVFSMDQTE
SLFKPHLMAMNSIFDSSGKGAVSEKSNFLFTKLKEEPEELAQLAPTPGDAIISLDFGNQN
FEESSAYGKAILPPSQPWATELRSHSTQSEAGSLPAFTVPQAAAPGSTTPSATSSSSSCS
TPNSPEDYYTSLDNDLKIEVIEKLFAMDTEAKDQCSTQTDFNELDLETLAPYIPMDGEDF
QLSPICPEERLLAENPQSTPQHCFSAMTNIFQPLAPVAPHSPFLLDKFQQQLESKKTEPE
HRPMSSIFFDAGSKASLPPCCGQASTPLSSMGGRSNTQWPPDPPLHFGPTKWAVGDQRTE
FLGAAPLGPPVSPPHVSTFKTRSAKGFGARGPDVLSPAMVALSNKLKLKRQLEYEEQAFQ
DLSGGDPPGGSTSHLMWKRMKNLRGGSCPLMPDKPLSANVPNDKFTQNPMRGLGHPLRHL
PLPQPPSAISPGENSKSRFPPQCYATQYQDYSLSSAHKVSGMASRLLGPSFESYLLPELT
RYDCEVNVPVLGSSTLLQGGDLLRALDQAT
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BDBM50498800 |
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n/a |
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Name | BDBM50498800 |
Synonyms: | CHEMBL3623811 |
Type | Small organic molecule |
Emp. Form. | C38H40O7 |
Mol. Mass. | 608.72 |
SMILES | COc1cc(ccc1O[C@H](C)C(=O)c1ccccc1)[C@H]1O[C@@H]([C@H](C)[C@H]1C)c1ccc(O[C@H](C)C(=O)c2ccccc2)c(OC)c1 |r| |
Structure |
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