| Reaction Details |
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 | Report a problem with these data |
| Target | Urokinase-type plasminogen activator |
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| Ligand | BDBM16173 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1543045 (CHEMBL3743968) |
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| IC50 | 11980±n/a nM |
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| Citation |  Gladysz, R; Adriaenssens, Y; De Winter, H; Joossens, J; Lambeir, AM; Augustyns, K; Van der Veken, P Discovery and SAR of Novel and Selective Inhibitors of Urokinase Plasminogen Activator (uPA) with an Imidazo[1,2-a]pyridine Scaffold. J Med Chem58:9238-57 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Urokinase-type plasminogen activator |
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| Name: | Urokinase-type plasminogen activator |
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| Synonyms: | 3.4.21.73 | PLAU | U-plasminogen activator | UROK_HUMAN | Urokinase | Urokinase-type plasminogen activator (uPA) | Urokinase-type plasminogen activator chain B | Urokinase-type plasminogen activator long chain A | Urokinase-type plasminogen activator short chain A | Urokinase-type plasminogen activator/surface receptor | uPA |
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| Type: | Enzyme |
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| Mol. Mass.: | 48528.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00749 |
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| Residue: | 431 |
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| Sequence: | MRALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQ
HCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHN
YCRNPDNRRRPWCYVQVGLKLLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKII
GGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLG
RSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICL
PSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKML
CAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIR
SHTKEENGLAL
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| BDBM16173 |
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| n/a |
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| Name | BDBM16173 |
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| Synonyms: | 3,5-diamino-6-chloro-N-(diaminomethylene)pyrazinamide;hydrochloride | 3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide | Amiloride | Amipramidin | CHEMBL945 |
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| Type | Small organic molecule |
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| Emp. Form. | C6H8ClN7O |
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| Mol. Mass. | 229.627 |
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| SMILES | NC(=N)NC(=O)c1nc(Cl)c(N)nc1N |
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| Structure | 
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