| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tubulin beta chain |
|---|
| Ligand | BDBM50014846 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1546324 (CHEMBL3748555) |
|---|
| IC50 | 2100±n/a nM |
|---|
| Citation |  Colley, HE; Muthana, M; Danson, SJ; Jackson, LV; Brett, ML; Harrison, J; Coole, SF; Mason, DP; Jennings, LR; Wong, M; Tulasi, V; Norman, D; Lockey, PM; Williams, L; Dossetter, AG; Griffen, EJ; Thompson, MJ An Orally Bioavailable, Indole-3-glyoxylamide Based Series of Tubulin Polymerization Inhibitors Showing Tumor Growth Inhibition in a Mouse Xenograft Model of Head and Neck Cancer. J Med Chem58:9309-33 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tubulin beta chain |
|---|
| Name: | Tubulin beta chain |
|---|
| Synonyms: | Beta-tubulin | TBB_PIG | Tubulin beta chain |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 49840.26 |
|---|
| Organism: | Sus scrofa |
|---|
| Description: | ChEMBL_105107 |
|---|
| Residue: | 445 |
|---|
| Sequence: | MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYV
PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMM
AACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATADEQGEFEEEGEEDEA
|
|
|
|---|
| BDBM50014846 |
|---|
| n/a |
|---|
| Name | BDBM50014846 |
|---|
| Synonyms: | (S)-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide | (S)-colchicine | 7alphaH-colchicine | CHEMBL107 | COLCHICINE | N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide | colchicina | colchicinum |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H25NO6 |
|---|
| Mol. Mass. | 399.437 |
|---|
| SMILES | COc1cc2CC[C@H](NC(C)=O)c3cc(=O)c(OC)ccc3-c2c(OC)c1OC |r| |
|---|
| Structure | 
|
|---|
Search and Browse
