Reaction Details |
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Target | Tubulin beta chain |
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Ligand | BDBM50500403 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1546324 (CHEMBL3748555) |
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IC50 | 2600±n/a nM |
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Citation | Colley, HE; Muthana, M; Danson, SJ; Jackson, LV; Brett, ML; Harrison, J; Coole, SF; Mason, DP; Jennings, LR; Wong, M; Tulasi, V; Norman, D; Lockey, PM; Williams, L; Dossetter, AG; Griffen, EJ; Thompson, MJ An Orally Bioavailable, Indole-3-glyoxylamide Based Series of Tubulin Polymerization Inhibitors Showing Tumor Growth Inhibition in a Mouse Xenograft Model of Head and Neck Cancer. J Med Chem58:9309-33 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tubulin beta chain |
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Name: | Tubulin beta chain |
Synonyms: | Beta-tubulin | TBB_PIG | Tubulin beta chain |
Type: | PROTEIN |
Mol. Mass.: | 49840.26 |
Organism: | Sus scrofa |
Description: | ChEMBL_105107 |
Residue: | 445 |
Sequence: | MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYV
PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMM
AACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATADEQGEFEEEGEEDEA
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BDBM50500403 |
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n/a |
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Name | BDBM50500403 |
Synonyms: | CHEMBL3746996 |
Type | Small organic molecule |
Emp. Form. | C18H18N4O4 |
Mol. Mass. | 354.3599 |
SMILES | COCCn1cc(C(=O)C(=O)Nc2ccc(OC)nc2)c2cccnc12 |
Structure |
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