Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Sterol O-acyltransferase 1 | ||
| Ligand | BDBM50051883 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_28661 (CHEMBL643995) | ||
| IC50 | 60±n/a nM | ||
| Citation |  Astles, PC; Ashton, MJ; Bridge, AW; Harris, NV; Hart, TW; Parrott, DP; Porter, B; Riddell, D; Smith, C; Williams, RJ Acyl-CoA:Cholesterol O-acyltransferase (ACAT) inhibitors. 2. 2-(1,3-Dioxan-2-yl)-4,5-diphenyl-1H-imidazoles as potent inhibitors of ACAT. J Med Chem39:1423-32 (1996) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Sterol O-acyltransferase 1 | |||
| Name: | Sterol O-acyltransferase 1 | ||
| Synonyms: | ACACT | ACACT1 | ACAT | ACAT1 | Acetyl-CoA acetyltransferase, mitochondrial | Acyl coenzyme A:cholesterol acyltransferase 1 | Acyl-CoA: cholesterol acyltransferase (ACAT) | Acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) | Cholesterol acyltransferase 1 | SOAT | SOAT1 | SOAT1_HUMAN | STAT | ||
| Type: | Multi-pass membrane protein may form homo- or heterodimers. | ||
| Mol. Mass.: | 64751.94 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P35610 | ||
| Residue: | 550 | ||
| Sequence: |
| ||
| BDBM50051883 | |||
| n/a | |||
| Name | BDBM50051883 | ||
| Synonyms: | 1-{5-[2-(4,5-Diphenyl-1H-imidazol-2-yl)-5-methyl-[1,3]dioxan-5-yl]-pentyl}-3,5-dimethyl-1H-pyrazole | CHEMBL285429 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C30H36N4O2 | ||
| Mol. Mass. | 484.6324 | ||
| SMILES | Cc1cc(C)n(CCCCCC2(C)COC(OC2)c2nc(c([nH]2)-c2ccccc2)-c2ccccc2)n1 |(10.96,-4.93,;10.8,-6.47,;9.47,-7.23,;9.8,-8.75,;8.77,-9.89,;11.34,-8.91,;12.12,-10.26,;11.03,-11.35,;11.8,-12.69,;11.05,-14.02,;11.83,-15.36,;11.84,-16.9,;13.17,-17.67,;11.08,-18.24,;9.36,-17.63,;8.18,-18.05,;8.94,-16.7,;10.57,-17.32,;6.84,-17.28,;6.43,-15.79,;4.9,-15.72,;4.34,-17.16,;5.55,-18.12,;2.85,-17.56,;1.77,-16.47,;.29,-16.88,;-.11,-18.37,;.99,-19.45,;2.47,-19.05,;4.04,-14.43,;4.74,-13.06,;3.9,-11.77,;2.36,-11.85,;1.68,-13.23,;2.52,-14.51,;11.96,-7.49,)| | ||
| Structure | 
| ||