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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Sterol O-acyltransferase 1 | ||
| Ligand | BDBM50051888 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_28658 (CHEMBL643993) | ||
| IC50 | 50±n/a nM | ||
| Citation |  Astles, PC; Ashton, MJ; Bridge, AW; Harris, NV; Hart, TW; Parrott, DP; Porter, B; Riddell, D; Smith, C; Williams, RJ Acyl-CoA:Cholesterol O-acyltransferase (ACAT) inhibitors. 2. 2-(1,3-Dioxan-2-yl)-4,5-diphenyl-1H-imidazoles as potent inhibitors of ACAT. J Med Chem39:1423-32 (1996) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Sterol O-acyltransferase 1 | |||
| Name: | Sterol O-acyltransferase 1 | ||
| Synonyms: | ACACT | ACACT1 | ACAT | ACAT1 | Acetyl-CoA acetyltransferase, mitochondrial | Acyl coenzyme A:cholesterol acyltransferase 1 | Acyl-CoA: cholesterol acyltransferase (ACAT) | Acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) | Cholesterol acyltransferase 1 | SOAT | SOAT1 | SOAT1_HUMAN | STAT | ||
| Type: | Multi-pass membrane protein may form homo- or heterodimers. | ||
| Mol. Mass.: | 64751.94 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P35610 | ||
| Residue: | 550 | ||
| Sequence: |
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| BDBM50051888 | |||
| n/a | |||
| Name | BDBM50051888 | ||
| Synonyms: | CHEMBL284378 | {4-[2-(4,5-Diphenyl-1H-imidazol-2-yl)-5-methyl-[1,3]dioxan-5-yl]-butyl}-methyl-pyridin-2-yl-amine | ||
| Type | Small organic molecule | ||
| Emp. Form. | C30H34N4O2 | ||
| Mol. Mass. | 482.6166 | ||
| SMILES | CN(CCCCC1(C)COC(OC1)c1nc(c([nH]1)-c1ccccc1)-c1ccccc1)c1ccccn1 |(11.88,.67,;10.34,.67,;9.95,-.82,;10.74,-2.15,;9.97,-3.48,;10.69,-4.74,;9.55,-5.82,;10.65,-6.89,;8.8,-7.15,;7.08,-6.54,;5.89,-6.96,;6.66,-5.61,;8.29,-6.24,;4.56,-6.19,;4.14,-4.7,;2.62,-4.63,;2.06,-6.05,;3.27,-7.03,;.57,-6.47,;-.51,-5.37,;-2,-5.77,;-2.4,-7.26,;-1.3,-8.36,;.19,-7.94,;1.76,-3.32,;2.46,-1.94,;1.62,-.66,;.08,-.75,;-.6,-2.13,;.24,-3.41,;10.34,2.21,;8.99,2.98,;8.97,4.5,;10.3,5.29,;11.65,4.54,;11.67,3,)| | ||
| Structure | 
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