Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Sterol O-acyltransferase 1 | ||
Ligand | BDBM50051898 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_28658 (CHEMBL643993) | ||
IC50 | 50±n/a nM | ||
Citation | Astles, PC; Ashton, MJ; Bridge, AW; Harris, NV; Hart, TW; Parrott, DP; Porter, B; Riddell, D; Smith, C; Williams, RJ Acyl-CoA:Cholesterol O-acyltransferase (ACAT) inhibitors. 2. 2-(1,3-Dioxan-2-yl)-4,5-diphenyl-1H-imidazoles as potent inhibitors of ACAT. J Med Chem39:1423-32 (1996) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Sterol O-acyltransferase 1 | |||
Name: | Sterol O-acyltransferase 1 | ||
Synonyms: | ACACT | ACACT1 | ACAT | ACAT1 | Acetyl-CoA acetyltransferase, mitochondrial | Acyl coenzyme A:cholesterol acyltransferase 1 | Acyl-CoA: cholesterol acyltransferase (ACAT) | Acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) | Cholesterol acyltransferase 1 | SOAT | SOAT1 | SOAT1_HUMAN | STAT | ||
Type: | Multi-pass membrane protein may form homo- or heterodimers. | ||
Mol. Mass.: | 64751.94 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P35610 | ||
Residue: | 550 | ||
Sequence: |
| ||
BDBM50051898 | |||
n/a | |||
Name | BDBM50051898 | ||
Synonyms: | 1-{4-[2-(4,5-Diphenyl-1H-imidazol-2-yl)-5-methyl-[1,3]dioxan-5-yl]-butyl}-4-thiazol-2-yl-piperazine | CHEMBL34219 | ||
Type | Small organic molecule | ||
Emp. Form. | C31H37N5O2S | ||
Mol. Mass. | 543.723 | ||
SMILES | CC1(CCCCN2CCN(CC2)c2nccs2)COC(OC1)c1nc(c([nH]1)-c1ccccc1)-c1ccccc1 |(14.14,-13.82,;12.81,-13.05,;13.21,-11.57,;12.13,-10.48,;12.54,-8.99,;11.46,-7.89,;11.88,-6.4,;13.35,-6.03,;13.77,-4.55,;12.7,-3.44,;11.21,-3.83,;10.79,-5.32,;13.12,-1.96,;11.98,-.93,;12.58,.48,;14.12,.33,;14.45,-1.17,;11.53,-13.47,;9.9,-12.86,;9.15,-14.21,;10.32,-13.79,;12.05,-14.4,;7.8,-13.42,;7.4,-11.93,;5.86,-11.86,;5.3,-13.31,;6.51,-14.28,;3.81,-13.7,;3.43,-15.2,;1.94,-15.59,;.85,-14.52,;1.24,-13.03,;2.73,-12.62,;5,-10.58,;5.7,-9.2,;4.86,-7.92,;3.32,-7.99,;2.64,-9.38,;3.48,-10.66,)| | ||
Structure |