Ki Summary

Reaction Details

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Target

D(3) dopamine receptor

Ligand

BDBM50052181

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_62756 (CHEMBL674596)

1.7±n/a nM

Citation

Ohmori, J; Maeno, K; Hidaka, K; Nakato, K; Matsumoto, M; Tada, S; Hattori, H; Sakamoto, S; Tsukamoto, S; Usuda, S; Mase, T Dopamine D3 and D4 receptor antagonists: synthesis and structure--activity relationships of (S)-(+)-N-(1-Benzyl-3-pyrrolidinyl)-5-chloro-4- [(cyclopropylcarbonyl) amino]-2-methoxybenzamide (YM-43611) and related compounds. J Med Chem39:2764-72 (1996) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

D(3) dopamine receptor

Name:

D(3) dopamine receptor

Synonyms:

DOPAMINE D3 | DRD3_RAT | Dopamine D3 receptor | Drd3

Type:

Protein

Mol. Mass.:

49540.58

Organism:

Rattus norvegicus (Rat)

Description:

P19020

Residue:

446

Sequence:

MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERAL
QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILN
LCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSI
CSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQ
QSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLK
RYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGP
LQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYV
NSALNPVIYTTFNVEFRKAFLKILSC

BDBM50052181

n/a

Name

BDBM50052181

Synonyms:

CHEMBL92924 | N-((S)-1-Adamantan-2-yl-pyrrolidin-3-yl)-5-chloro-4-(cyclopropanecarbonyl-amino)-2-methoxy-benzamide

Type

Small organic molecule

Emp. Form.

C26H34ClN3O3

Mol. Mass.

472.019

SMILES

COc1cc(NC(=O)C2CC2)c(Cl)cc1C(=O)N[C@H]1CCN(C1)C1C2CC3CC(C2)CC1C3 |wU:18.19,TLB:29:24:32:28.30.27,29:28:23.24.25:32,THB:21:23:32:28.30.27,27:28:23:26.25.32,27:26:23:28.30.29,(5.91,-4.27,;5.93,-2.73,;4.6,-1.96,;3.25,-2.73,;1.92,-1.96,;.59,-2.73,;-.74,-1.96,;-.74,-.4,;-2.08,-2.73,;-3.62,-2.73,;-2.85,-4.06,;1.92,-.4,;.59,.35,;3.25,.37,;4.6,-.4,;5.93,.37,;5.93,1.91,;7.23,-.4,;8.34,.69,;8.34,2.23,;11,2.24,;11.07,.74,;9.68,-.08,;12.42,,;13.77,.48,;12.72,-.75,;12.72,-2.34,;14.14,-2.9,;15.15,-1.62,;15.15,-.1,;13.75,-1.97,;12.42,-1.48,;11.23,-2.76,)|

Structure