Reaction Details |
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Target | Tyrosine-protein kinase ZAP-70 |
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Ligand | BDBM50503098 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1809401 (CHEMBL4308760) |
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EC50 | 28±n/a nM |
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Citation | O'Malley, DP; Ahuja, V; Fink, B; Cao, C; Wang, C; Swanson, J; Wee, S; Gavai, AV; Tokarski, J; Critton, D; Paiva, AA; Johnson, BM; Szapiel, N; Xie, D Discovery of Pyridazinone and Pyrazolo[1,5- ACS Med Chem Lett10:1486-1491 (2019) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase ZAP-70 |
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Name: | Tyrosine-protein kinase ZAP-70 |
Synonyms: | 70 kDa zeta-associated protein | SRK | Syk-related tyrosine kinase | Tyrosine Kinase ZAP-70 | Tyrosine-protein kinase ZAP-70 | Tyrosine-protein kinase ZAP-70 (Syk) | Tyrosine-protein kinase ZAP-70 (ZAP70) | Tyrosine-protein kinase ZAP70 | ZAP70 | ZAP70_HUMAN | Zeta-chain (TCR) associated protein kinase 70kDa |
Type: | Enzyme |
Mol. Mass.: | 69881.61 |
Organism: | Homo sapiens (Human) |
Description: | ZAP-70 SH2 domain was expressed and purified from E. coli using O-phospho-L-tyrosine-agarose column. |
Residue: | 619 |
Sequence: | MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFP
IERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFDCLRD
AMVRDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSG
AQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLK
LKADGLIYCLKEACPNSSASNASGAAAPTLPAHPSTLTHPQRRIDTLNSDGYTPEPARIT
SPDKPRPMPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMR
KKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGG
PLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDF
GLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPY
KKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSL
ASKVEGPPGSTQKAEAACA
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BDBM50503098 |
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n/a |
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Name | BDBM50503098 |
Synonyms: | CHEMBL4582324 |
Type | Small organic molecule |
Emp. Form. | C34H38N8O4 |
Mol. Mass. | 622.7167 |
SMILES | COc1ccc2c(cnn2c1)C(=O)Nc1ccc(NC(=O)c2nn(C3CCN(CC3)C(=O)NC(C)(C)C)c3ccccc23)cc1C |
Structure |
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