| Reaction Details |
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 | Report a problem with these data |
| Target | Chitotriosidase-1 |
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| Ligand | BDBM50504024 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1813250 (CHEMBL4312824) |
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| IC50 | 74±n/a nM |
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| Citation |  Mazur, M; Dymek, B; Koralewski, R; Sklepkiewicz, P; Olejniczak, S; Mazurkiewicz, M; Piotrowicz, M; Salamon, M; J?drzejczak, K; Zagozdzon, A; Czestkowski, W; Matyszewski, K; Borek, B; Bartoszewicz, A; Pluta, E; Rymaszewska, A; Mozga, W; Stefaniak, F; Dobrza?ski, P; Dzwonek, K; Golab, J; Golebiowski, A; Olczak, J Development of Dual Chitinase Inhibitors as Potential New Treatment for Respiratory System Diseases. J Med Chem62:7126-7145 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Chitotriosidase-1 |
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| Name: | Chitotriosidase-1 |
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| Synonyms: | 3.2.1.14 | CHIT1_MOUSE | Chit1 | Chitinase-1 | Chitotriosidase-1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 51108.04 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_117450 |
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| Residue: | 464 |
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| Sequence: | MVQSLAWAGVMTLLMVQWGSAAKLVCYLTNWSQYRTEAVRFFPRDVDPNLCTHVIFAFAG
MDNHQLSTVEHNDELLYQELNSLKTKNPKLKTLLAVGGWTFGTQKFTDMVATASNRQTFV
KSALSFLRTQGFDGLDLDWEFPGGRGSPTVDKERFTALIQDLAKAFQEEAQSSGKERLLL
TAAVPSDRGLVDAGYEVDKIAQSLDFINLMAYDFHSSLEKTTGHNSPLYKRQGESGAAAE
QNVDAAVTLWLQKGTPASKLILGMPTYGRSFTLASSSDNGVGAPATGPGAPGPYTKDKGV
LAYYEACSWKERHRIEDQKVPYAFQDNQWVSFDDVESFKAKAAYLKQKGLGGAMVWVLDL
DDFKGSFCNQGPYPLIRTLRQELNLPSETPRSPEQIIPEPRPSSMPEQGPSPGLDNFCQG
KADGVYPNPGDESTYYNCGGGRLFQQSCPPGLVFRASCKCCTWS
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| BDBM50504024 |
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| n/a |
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| Name | BDBM50504024 |
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| Synonyms: | CHEMBL4461925 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H25ClN6O |
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| Mol. Mass. | 376.884 |
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| SMILES | Nc1n[nH]c(n1)N1CCC(CC1)N1CCOC[C@@H]1Cc1ccc(Cl)cc1 |r| |
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| Structure | 
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