| Reaction Details |
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 | Report a problem with these data |
| Target | ATPase family AAA domain-containing protein 2 |
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| Ligand | BDBM50504166 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1813632 (CHEMBL4313206) |
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| IC50 | 30±n/a nM |
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| Citation |  Bamborough, P; Chung, CW; Demont, EH; Bridges, AM; Craggs, PD; Dixon, DP; Francis, P; Furze, RC; Grandi, P; Jones, EJ; Karamshi, B; Locke, K; Lucas, SCC; Michon, AM; Mitchell, DJ; Pogány, P; Prinjha, RK; Rau, C; Roa, AM; Roberts, AD; Sheppard, RJ; Watson, RJ A Qualified Success: Discovery of a New Series of ATAD2 Bromodomain Inhibitors with a Novel Binding Mode Using High-Throughput Screening and Hit Qualification. J Med Chem62:7506-7525 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| ATPase family AAA domain-containing protein 2 |
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| Name: | ATPase family AAA domain-containing protein 2 |
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| Synonyms: | AAA nuclear coregulator cancer-associated protein | ANCCA | ATAD2 | ATAD2_HUMAN | PRO2000 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 158546.30 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1500426 |
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| Residue: | 1390 |
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| Sequence: | MVVLRSSLELHNHSAASATGSLDLSSDFLSLEHIGRRRLRSAGAAQKKPAATTAKAGDGS
SVKEVETYHRTRALRSLRKDAQNSSDSSFEKNVEITEQLANGRHFTRQLARQQADKKKEE
HREDKVIPVTRSLRARNIVQSTEHLHEDNGDVEVRRSCRIRSRYSGVNQSMLFDKLITNT
AEAVLQKMDDMKKMRRQRMRELEDLGVFNETEESNLNMYTRGKQKDIQRTDEETTDNQEG
SVESSEEGEDQEHEDDGEDEDDEDDDDDDDDDDDDDDEDDEDEEDGEEENQKRYYLRQRK
ATVYYQAPLEKPRHQRKPNIFYSGPASPARPRYRLSSAGPRSPYCKRMNRRRHAIHSSDS
TSSSSSEDEQHFERRRKRSRNRAINRCLPLNFRKDELKGIYKDRMKIGASLADVDPMQLD
SSVRFDSVGGLSNHIAALKEMVVFPLLYPEVFEKFKIQPPRGCLFYGPPGTGKTLVARAL
ANECSQGDKRVAFFMRKGADCLSKWVGESERQLRLLFDQAYQMRPSIIFFDEIDGLAPVR
SSRQDQIHSSIVSTLLALMDGLDSRGEIVVIGATNRLDSIDPALRRPGRFDREFLFSLPD
KEARKEILKIHTRDWNPKPLDTFLEELAENCVGYCGADIKSICAEAALCALRRRYPQIYT
TSEKLQLDLSSINISAKDFEVAMQKMIPASQRAVTSPGQALSTVVKPLLQNTVDKILEAL
QRVFPHAEFRTNKTLDSDISCPLLESDLAYSDDDVPSVYENGLSQKSSHKAKDNFNFLHL
NRNACYQPMSFRPRILIVGEPGFGQGSHLAPAVIHALEKFTVYTLDIPVLFGVSTTSPEE
TCAQVIREAKRTAPSIVYVPHIHVWWEIVGPTLKATFTTLLQNIPSFAPVLLLATSDKPH
SALPEEVQELFIRDYGEIFNVQLPDKEERTKFFEDLILKQAAKPPISKKKAVLQALEVLP
VAPPPEPRSLTAEEVKRLEEQEEDTFRELRIFLRNVTHRLAIDKRFRVFTKPVDPDEVPD
YVTVIKQPMDLSSVISKIDLHKYLTVKDYLRDIDLICSNALEYNPDRDPGDRLIRHRACA
LRDTAYAIIKEELDEDFEQLCEEIQESRKKRGCSSSKYAPSYYHVMPKQNSTLVGDKRSD
PEQNEKLKTPSTPVACSTPAQLKRKIRKKSNWYLGTIKKRRKISQAKDDSQNAIDHKIES
DTEETQDTSVDHNETGNTGESSVEENEKQQNASESKLELRNNSNTCNIENELEDSRKTTA
CTELRDKIACNGDASSSQIIHISDENEGKEMCVLRMTRARRSQVEQQQLITVEKALAILS
QPTPSLVVDHERLKNLLKTVVKKSQNYNIFQLENLYAVISQCIYRHRKDHDKTSLIQKME
QEVENFSCSR
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| BDBM50504166 |
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| n/a |
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| Name | BDBM50504166 |
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| Synonyms: | CHEMBL4529901 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H20N6O |
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| Mol. Mass. | 336.391 |
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| SMILES | CN1CCN(CC1)c1nc(C(=O)c2ccccc2)c2cnn(C)c2n1 |
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| Structure | 
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