| Reaction Details |
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 | Report a problem with these data |
| Target | Nuclear factor erythroid 2-related factor 2 |
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| Ligand | BDBM50504656 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1815979 (CHEMBL4315553) |
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| EC50 | 1460±n/a nM |
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| Citation |  Kim, HJ; Jang, BK; Park, JH; Choi, JW; Park, SJ; Byeon, SR; Pae, AN; Lee, YS; Cheong, E; Park, KD A novel chalcone derivative as Nrf2 activator attenuates learning and memory impairment in a scopolamine-induced mouse model. Eur J Med Chem185:0 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nuclear factor erythroid 2-related factor 2 |
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| Name: | Nuclear factor erythroid 2-related factor 2 |
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| Synonyms: | HEBP1 | Kelch-like ECH-associated protein 1 | NF-E2-related factor 2 | NF2L2_HUMAN | NFE2-related factor 2 | NFE2L2 | NRF2 | Nuclear factor erythroid 2-related factor 2 | Nuclear factor, erythroid derived 2, like 2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 67786.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_107924 |
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| Residue: | 605 |
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| Sequence: | MMDLELPPPGLPSQQDMDLIDILWRQDIDLGVSREVFDFSQRRKEYELEKQKKLEKERQE
QLQKEQEKAFFAQLQLDEETGEFLPIQPAQHIQSETSGSANYSQVAHIPKSDALYFDDCM
QLLAQTFPFVDDNEVSSATFQSLVPDIPGHIESPVFIATNQAQSPETSVAQVAPVDLDGM
QQDIEQVWEELLSIPELQCLNIENDKLVETTMVPSPEAKLTEVDNYHFYSSIPSMEKEVG
NCSPHFLNAFEDSFSSILSTEDPNQLTVNSLNSDATVNTDFGDEFYSAFIAEPSISNSMP
SPATLSHSLSELLNGPIDVSDLSLCKAFNQNHPESTAEFNDSDSGISLNTSPSVASPEHS
VESSSYGDTLLGLSDSEVEELDSAPGSVKQNGPKTPVHSSGDMVQPLSPSQGQSTHVHDA
QCENTPEKELPVSPGHRKTPFTKDKHSSRLEAHLTRDELRAKALHIPFPVEKIINLPVVD
FNEMMSKEQFNEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLDHLKDEKEKLL
KEKGENDKSLHLLKKQLSTLYLEVFSMLRDEDGKPYSPSEYSLQQTRDGNVFLVPKSKKP
DVKKN
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| BDBM50504656 |
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| n/a |
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| Name | BDBM50504656 |
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| Synonyms: | CHEMBL1549549 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H18N2O3 |
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| Mol. Mass. | 310.3471 |
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| SMILES | CN(C)C(=O)COc1ccc(cc1)C(=O)\C=C\c1cccnc1 |
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| Structure | 
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