| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Broad substrate specificity ATP-binding cassette transporter ABCG2 |
|---|
| Ligand | BDBM50465853 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1822759 (CHEMBL4322523) |
|---|
| EC50 | 135±n/a nM |
|---|
| Citation |  Zhu, X; Wong, ILK; Chan, KF; Cui, J; Law, MC; Chong, TC; Hu, X; Chow, LMC; Chan, TH Triazole Bridged Flavonoid Dimers as Potent, Nontoxic, and Highly Selective Breast Cancer Resistance Protein (BCRP/ABCG2) Inhibitors. J Med Chem62:8578-8608 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 |
|---|
| Name: | Broad substrate specificity ATP-binding cassette transporter ABCG2 |
|---|
| Synonyms: | ABCG2 | ABCG2_HUMAN | ABCP | ATP-Binding Cassette Transporter ABCG2 | ATP-binding cassette sub-family G member 2 | ATP-binding cassette transporter (ABCG2) | ATP-binding cassette, sub-family G, member 2 | BCRP | BCRP1 | Breast cancer resistance protein | CDw338 | MXR | Mitoxantrone resistance-associated protein | Placenta-specific ATP-binding cassette transporter | Urate exporter |
|---|
| Type: | Multi-pass membrane protein; monomer or homodimer; disulfide-linked |
|---|
| Mol. Mass.: | 72329.48 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9UNQ0 |
|---|
| Residue: | 655 |
|---|
| Sequence: | MSSSNVEVFIPVSQGNTNGFPATASNDLKAFTEGAVLSFHNICYRVKLKSGFLPCRKPVE
KEILSNINGIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANFKCN
SGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGT
QFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIF
SIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADFFLDIING
DSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKETKAELHQLSGGEKKKK
ITVFKEISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVIGAIYFGLKNDS
TGIQNRAGVLFFLTTNQCFSSVSAVELFVVEKKLFIHEYISGYYRVSSYFLGKLLSDLLP
MRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIAAGQSVVSVATLL
MTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFLGQNFCPGLNATGN
NPCNYATCTGEEYLVKQGIDLSPWGLWKNHVALACMIVIFLTIAYLKLLFLKKYS
|
|
|
|---|
| BDBM50465853 |
|---|
| n/a |
|---|
| Name | BDBM50465853 |
|---|
| Synonyms: | CHEMBL4283314 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C41H37N3O7 |
|---|
| Mol. Mass. | 683.7484 |
|---|
| SMILES | Cc1ccc2oc(cc(=O)c2c1)-c1ccc(OCCCCc2cn(CCOCCOc3ccc4c(c3)oc(cc4=O)-c3ccccc3)nn2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
