| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Kappa-type opioid receptor |
|---|
| Ligand | BDBM50506231 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1825158 (CHEMBL4324922) |
|---|
| Ki | 0.750000±n/a nM |
|---|
| Citation |  Ma, H; Obeng, S; Wang, H; Zheng, Y; Li, M; Jali, AM; Stevens, DL; Dewey, WL; Selley, DE; Zhang, Y Application of Bivalent Bioisostere Concept on Design and Discovery of Potent Opioid Receptor Modulators. J Med Chem62:11399-11415 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Kappa-type opioid receptor |
|---|
| Name: | Kappa-type opioid receptor |
|---|
| Synonyms: | KOR-1 | MSL-1 | OPIATE Kappa | OPRK_MOUSE | Oprk1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 42656.78 |
|---|
| Organism: | Mus musculus (Mouse) |
|---|
| Description: | P33534 |
|---|
| Residue: | 380 |
|---|
| Sequence: | MESPIQIFRGDPGPTCSPSACLLPNSSSWFPNWAESDSNGSVGSEDQQLESAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSAVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALG
STSHSTAALSSYYFCIALGYTNSSLNPVLYAFLDENFKRCFRDFCFPIKMRMERQSTNRV
RNTVQDPASMRDVGGMNKPV
|
|
|
|---|
| BDBM50506231 |
|---|
| n/a |
|---|
| Name | BDBM50506231 |
|---|
| Synonyms: | CHEMBL4575933 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H31ClN2O4S |
|---|
| Mol. Mass. | 539.085 |
|---|
| SMILES | Cl.[H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]5(O)CC[C@H]2NC(=O)c1cccc2sccc12)ccc3O |r,THB:11:10:18:7.6.5| |
|---|
| Structure | 
|
|---|
Search and Browse
