| Reaction Details |
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 | Report a problem with these data |
| Target | Death-associated protein kinase 1 |
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| Ligand | BDBM50506351 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1825582 (CHEMBL4325346) |
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| IC50 | 203±n/a nM |
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| Citation |  Kurasawa, O; Miyazaki, T; Homma, M; Oguro, Y; Imada, T; Uchiyama, N; Iwai, K; Yamamoto, Y; Ohori, M; Hara, H; Sugimoto, H; Iwata, K; Skene, R; Hoffman, I; Ohashi, A; Nomura, T; Cho, N Discovery of a Novel, Highly Potent, and Selective Thieno[3,2- J Med Chem63:1084-1104 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Death-associated protein kinase 1 |
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| Name: | Death-associated protein kinase 1 |
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| Synonyms: | Cellular tumor antigen p53/Death-associated protein kinase 1 | DAP kinase 1 | DAPK | DAPK1 | DAPK1_HUMAN | Death-associated protein kinase 1 | Death-associated protein kinase 1 (DAPK1) | Death-associated protein kinase 2 (DAPK2) | Death-associated protein kinase 3 (DAPK3) |
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| Type: | PROTEIN |
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| Mol. Mass.: | 160053.35 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1517177 |
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| Residue: | 1430 |
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| Sequence: | MTVFRQENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSRED
IEREVSILKEIQHPNVITLHEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATEFL
KQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGT
PEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEY
FSNTSALAKDFIRRLLVKDPKKRMTIQDSLQHPWIKPKDTQQALSRKASAVNMEKFKKFA
ARKKWKQSVRLISLCQRLSRSFLSRSNMSVARSDDTLDEEDSFVMKAIIHAINDDNVPGL
QHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAA
RHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEET
PLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNAC
DKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEAN
CNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAG
LLARLRKDTHRGLFIQQLRPTQNLQPRIKLKLFGHSGSGKTTLVESLKCGLLRSFFRRRR
PRLSSTNSSRFPPSPLASKPTVSVSINNLYPGCENVSVRSRSMMFEPGLTKGMLEVFVAP
THHPHCSADDQSTKAIDIQNAYLNGVGDFSVWEFSGNPVYFCCYDYFAANDPTSIHVVVF
SLEEPYEIQLNQVIFWLSFLKSLVPVEEPIAFGGKLKNPLQVVLVATHADIMNVPRPAGG
EFGYDKDTSLLKEIRNRFGNDLHISNKLFVLDAGASGSKDMKVLRNHLQEIRSQIVSVCP
PMTHLCEKIISTLPSWRKLNGPNQLMSLQQFVYDVQDQLNPLASEEDLRRIAQQLHSTGE
INIMQSETVQDVLLLDPRWLCTNVLGKLLSVETPRALHHYRGRYTVEDIQRLVPDSDVEE
LLQILDAMDICARDLSSGTMVDVPALIKTDNLHRSWADEEDEVMVYGGVRIVPVEHLTPF
PCGIFHKVQVNLCRWIHQQSTEGDADIRLWVNGCKLANRGAELLVLLVNHGQGIEVQVRG
LETEKIKCCLLLDSVCSTIENVMATTLPGLLTVKHYLSPQQLREHHEPVMIYQPRDFFRA
QTLKETSLTNTMGGYKESFSSIMCFGCHDVYSQASLGMDIHASDLNLLTRRKLSRLLDPP
DPLGKDWCLLAMNLGLPDLVAKYNTSNGAPKDFLPSPLHALLREWTTYPESTVGTLMSKL
RELGRRDAADFLLKASSVFKINLDGNGQEAYASSCNSGTSYNSISSVVSR
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| BDBM50506351 |
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| n/a |
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| Name | BDBM50506351 |
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| Synonyms: | CHEMBL4439133 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H19Cl2N5OS |
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| Mol. Mass. | 388.315 |
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| SMILES | Cl.Cl.Cc1n[nH]cc1-c1cc2nc([nH]c(=O)c2s1)[C@@H]1CCCCN1 |r| |
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| Structure | 
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