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Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Endothelial lipase | ||
| Ligand | BDBM50506737 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1827144 (CHEMBL4327018) | ||
| IC50 | 59±n/a nM | ||
| Citation |  Hu, CH; Wang, TC; Qiao, JX; Haque, L; Chen, AYA; Taylor, DS; Ying, X; Onorato, JM; Galella, M; Shen, H; Huang, CS; Toussaint, N; Li, YX; Abell, L; Adam, LP; Gordon, D; Wexler, RR; Finlay, HJ Discovery and synthesis of tetrahydropyrimidinedione-4-carboxamides as endothelial lipase inhibitors. Bioorg Med Chem Lett28:3721-3725 (2018) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Endothelial lipase | |||
| Name: | Endothelial lipase | ||
| Synonyms: | EDL | EL | Endothelial cell-derived lipase | LIPE_HUMAN | LIPG | ||
| Type: | Protein | ||
| Mol. Mass.: | 56805.62 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q9Y5X9 | ||
| Residue: | 500 | ||
| Sequence: |
| ||
| BDBM50506737 | |||
| n/a | |||
| Name | BDBM50506737 | ||
| Synonyms: | CHEMBL4555254 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H27N3O4 | ||
| Mol. Mass. | 385.4568 | ||
| SMILES | CC(C)Cn1c(=O)[nH]c(C(=O)N[C@H]2CC[C@H](CC2)c2ccccc2)c(O)c1=O |r,wU:12.11,15.18,(50.18,-52.33,;48.85,-51.57,;47.52,-52.33,;48.85,-50.03,;47.52,-49.27,;46.18,-50.04,;46.18,-51.58,;44.85,-49.27,;44.85,-47.73,;43.51,-46.97,;43.5,-45.43,;42.18,-47.74,;40.84,-46.98,;39.52,-47.75,;38.18,-46.98,;38.18,-45.44,;39.51,-44.67,;40.84,-45.44,;36.84,-44.67,;36.85,-43.13,;35.51,-42.36,;34.18,-43.13,;34.18,-44.68,;35.52,-45.44,;46.18,-46.95,;46.17,-45.41,;47.51,-47.72,;48.85,-46.96,)| | ||
| Structure | 
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