Reaction Details | |||
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Target | Proto-oncogene tyrosine-protein kinase Src | ||
Ligand | BDBM3450 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_216986 (CHEMBL822802) | ||
IC50 | 23±n/a nM | ||
Citation | Hamby, JM; Connolly, CJ; Schroeder, MC; Winters, RT; Showalter, HD; Panek, RL; Major, TC; Olsewski, B; Ryan, MJ; Dahring, T; Lu, GH; Keiser, J; Amar, A; Shen, C; Kraker, AJ; Slintak, V; Nelson, JM; Fry, DW; Bradford, L; Hallak, H; Doherty, AM Structure-activity relationships for a novel series of pyrido[2,3-d]pyrimidine tyrosine kinase inhibitors. J Med Chem40:2296-303 (1997) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Proto-oncogene tyrosine-protein kinase Src | |||
Name: | Proto-oncogene tyrosine-protein kinase Src | ||
Synonyms: | Calmodulin/Proto-oncogene tyrosine-protein kinase Src | Protein cereblon/Tyrosine-protein kinase SRC | Proto-oncogene c-Src | Proto-oncogene tyrosine-protein kinase Src (c-Src) | SRC | SRC1 | SRC_HUMAN | Tyrosine-protein kinase Src (SRC) | V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | c-Src | p60-Src | pp60c-src | ||
Type: | Protein | ||
Mol. Mass.: | 59838.60 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P12931 | ||
Residue: | 536 | ||
Sequence: |
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BDBM3450 | |||
n/a | |||
Name | BDBM3450 | ||
Synonyms: | 1-[6-(2,6-dichlorophenyl)-2-{[4-(diethylamino)butyl]amino}pyrido[2,3-d]pyrimidin-7-yl]-3-ethylurea | 6-arylpyrido[2,3-d]pyrimidine deriv. 32 | CHEMBL301483 | ||
Type | Small organic molecule | ||
Emp. Form. | C24H31Cl2N7O | ||
Mol. Mass. | 504.455 | ||
SMILES | CCNC(=O)Nc1nc2nc(NCCCCN(CC)CC)ncc2cc1-c1c(Cl)cccc1Cl |(5.49,-4.29,;4.16,-3.52,;4.16,-1.98,;2.83,-1.21,;1.49,-1.98,;2.83,.33,;1.49,1.1,;.16,.33,;-1.17,1.1,;-2.51,.33,;-3.84,1.1,;-5.18,.33,;-6.51,1.1,;-8,.7,;-9.09,1.79,;-10.57,1.39,;-11.66,2.48,;-13.15,2.08,;-13.55,.59,;-11.26,3.96,;-9.78,4.36,;-3.84,2.64,;-2.51,3.41,;-1.17,2.64,;.16,3.41,;1.49,2.64,;2.83,3.41,;2.83,4.95,;1.49,5.72,;4.16,5.72,;5.49,4.95,;5.49,3.41,;4.16,2.64,;4.16,1.1,)| | ||
Structure |