Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Epidermal growth factor receptor | ||
| Ligand | BDBM3431 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_66897 (CHEMBL675521) | ||
| IC50 | 6200±n/a nM | ||
| Citation |  Hamby, JM; Connolly, CJ; Schroeder, MC; Winters, RT; Showalter, HD; Panek, RL; Major, TC; Olsewski, B; Ryan, MJ; Dahring, T; Lu, GH; Keiser, J; Amar, A; Shen, C; Kraker, AJ; Slintak, V; Nelson, JM; Fry, DW; Bradford, L; Hallak, H; Doherty, AM Structure-activity relationships for a novel series of pyrido[2,3-d]pyrimidine tyrosine kinase inhibitors. J Med Chem40:2296-303 (1997) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Epidermal growth factor receptor | |||
| Name: | Epidermal growth factor receptor | ||
| Synonyms: | EGF Receptor Substrate | EGFR | EGFR_HUMAN | ERBB | ERBB1 | Epidermal Growth Factor Receptor Tyrosine Kinase | Epidermal Growth Factor Receptor erbB-1 | Epidermal Growth Factor Receptor, ErbB-1 | Epidermal growth factor receptor (EGFR) | Epidermal growth factor receptor (HER1) | HER1 | Protein-Tyrosine Kinase Erbb-1 | Proto-oncogene c-ErbB-1 | Receptor tyrosine-protein kinase ErbB-1 | Tyrosine-Protein Kinase ErbB-1 | ||
| Type: | Receptor Kinase Domain | ||
| Mol. Mass.: | 134279.59 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P00533 | ||
| Residue: | 1210 | ||
| Sequence: |
| ||
| BDBM3431 | |||
| n/a | |||
| Name | BDBM3431 | ||
| Synonyms: | 3-tert-butyl-1-[6-(2,6-dichlorophenyl)-2-{[3-(diethylamino)propyl]amino}pyrido[2,3-d]pyrimidin-7-yl]urea | 6-arylpyrido[2,3-d]pyrimidine deriv. 13 | CHEMBL299026 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H33Cl2N7O | ||
| Mol. Mass. | 518.482 | ||
| SMILES | CCN(CC)CCCNc1ncc2cc(c(NC(=O)NC(C)(C)C)nc2n1)-c1c(Cl)cccc1Cl |(-13.7,2.41,;-12.93,1.08,;-11.44,.68,;-11.24,-.85,;-9.82,-1.44,;-10.11,1.45,;-8.78,.68,;-7.44,1.45,;-6.11,.68,;-4.78,1.45,;-4.78,2.99,;-3.44,3.76,;-2.11,2.99,;-.77,3.76,;.56,2.99,;.56,1.45,;1.89,.68,;1.89,-.86,;.56,-1.63,;3.23,-1.63,;4.56,-.86,;5.89,-1.63,;4.56,.68,;5.89,-.09,;-.77,.68,;-2.11,1.45,;-3.44,.68,;1.89,3.76,;1.89,5.3,;.56,6.07,;3.23,6.07,;4.56,5.3,;4.56,3.76,;3.23,2.99,;3.23,1.45,)| | ||
| Structure | 
| ||