Reaction Details |
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Target | Myeloperoxidase |
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Ligand | BDBM50507392 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1829870 (CHEMBL4329744) |
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IC50 | 4.6±n/a nM |
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Citation | Wurtz, NR; Viet, A; Shaw, SA; Dilger, A; Valente, MN; Khan, JA; Jusuf, S; Narayanan, R; Fernando, G; Lo, F; Liu, X; Locke, GA; Kopcho, L; Abell, LM; Sleph, P; Basso, M; Zhao, L; Wexler, RR; Duclos, F; Kick, EK Potent Triazolopyridine Myeloperoxidase Inhibitors. ACS Med Chem Lett9:1175-1180 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Myeloperoxidase |
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Name: | Myeloperoxidase |
Synonyms: | 84 kDa myeloperoxidase | 89 kDa myeloperoxidase | MPO | Mpo protein | Myeloperoxidase | Myeloperoxidase (MPO) | Myeloperoxidase heavy chain | Myeloperoxidase light chain | PERM_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 83888.32 |
Organism: | Homo sapiens (Human) |
Description: | P05164 |
Residue: | 745 |
Sequence: | MGVPFFSSLRCMVDLGPCWAGGLTAEMKLLLALAGLLAILATPQPSEGAAPAVLGEVDTS
LVLSSMEEAKQLVDKAYKERRESIKQRLRSGSASPMELLSYFKQPVAATRTAVRAADYLH
VALDLLERKLRSLWRRPFNVTDVLTPAQLNVLSKSSGCAYQDVGVTCPEQDKYRTITGMC
NNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTPGVKRNGFPVALARAVSNEIVRFPTD
QLTPDQERSLMFMQWGQLLDHDLDFTPEPAARASFVTGVNCETSCVQQPPCFPLKIPPND
PRIKNQADCIPFFRSCPACPGSNITIRNQINALTSFVDASMVYGSEEPLARNLRNMSNQL
GLLAVNQRFQDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSSEMPELTSMHTLLL
REHNRLATELKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLVLGPTAMRKYLPTYR
SYNDSVDPRIANVFTNAFRYGHTLIQPFMFRLDNRYQPMEPNPRVPLSRVFFASWRVVLE
GGIDPILRGLMATPAKLNRQNQIAVDEIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYN
AWRRFCGLPQPETVGQLGTVLRNLKLARKLMEQYGTPNNIDIWMGGVSEPLKRKGRVGPL
LACIIGTQFRKLRDGDRFWWENEGVFSMQQRQALAQISLPRIICDNTGITTVSKNNIFMS
NSYPRDFVNCSTLPALNLASWREAS
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BDBM50507392 |
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n/a |
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Name | BDBM50507392 |
Synonyms: | CHEMBL4548537 | US10981879, Example 11 |
Type | Small organic molecule |
Emp. Form. | C12H9Cl2N5S |
Mol. Mass. | 326.204 |
SMILES | Nc1cc(SCc2c(Cl)cccc2Cl)c2nn[nH]c2n1 |
Structure |
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