| Reaction Details |
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 | Report a problem with these data |
| Target | Pirin |
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| Ligand | BDBM31088 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1830006 (CHEMBL4329880) |
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| IC50 | >10000±n/a nM |
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| Citation |  Meyers, J; Chessum, NEA; Ali, S; Mok, NY; Wilding, B; Pasqua, AE; Rowlands, M; Tucker, MJ; Evans, LE; Rye, CS; O'Fee, L; Le Bihan, YV; Burke, R; Carter, M; Workman, P; Blagg, J; Brown, N; van Montfort, RLM; Jones, K; Cheeseman, MD Privileged Structures and Polypharmacology within and between Protein Families. ACS Med Chem Lett9:1199-1204 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Pirin |
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| Name: | Pirin |
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| Synonyms: | PIR | PIR_HUMAN | Probable quercetin 2,3-dioxygenase PIR | Probable quercetinase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 32115.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_811273 |
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| Residue: | 290 |
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| Sequence: | MGSSKKVTLSVLSREQSEGVGARVRRSIGRPELKNLDPFLLFDEFKGGRPGGFPDHPHRG
FETVSYLLEGGSMAHEDFCGHTGKMNPGDLQWMTAGRGILHAEMPCSEEPAHGLQLWVNL
RSSEKMVEPQYQELKSEEIPKPSKDGVTVAVISGEALGIKSKVYTRTPTLYLDFKLDPGA
KHSQPIPKGWTSFIYTISGDVYIGPDDAQQKIEPHHTAVLGEGDSVQVENKDPKRSHFVL
IAGEPLREPVIQHGPFVMNTNEEISQAILDFRNAKNGFERAKTWKSKIGN
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| BDBM31088 |
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| n/a |
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| Name | BDBM31088 |
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| Synonyms: | 1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxy-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine | 1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-2-benzimidazolamine | CHIR-265 | [1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridyl]oxy]benzimidazol-2-yl]-[4-(trifluoromethyl)phenyl]amine | cid_11656518 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H16F6N6O |
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| Mol. Mass. | 518.4139 |
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| SMILES | Cn1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(Oc3ccnc(c3)-c3ncc([nH]3)C(F)(F)F)ccc12 |
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| Structure | 
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