| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 1 |
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| Ligand | BDBM50508183 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1832204 (CHEMBL4332212) |
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| IC50 | 1.4±n/a nM |
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| Citation |  Harcken, C; Kuzmich, D; Cook, B; Mao, C; Disalvo, D; Razavi, H; Swinamer, A; Liu, P; Zhang, Q; Kukulka, A; Skow, D; Patel, M; Patel, M; Fletcher, K; Sherry, T; Joseph, D; Smith, D; Canfield, M; Souza, D; Bogdanffy, M; Berg, K; Brown, M Identification of novel azaindazole CCR1 antagonist clinical candidates. Bioorg Med Chem Lett29:441-448 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 1 |
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| Name: | C-C chemokine receptor type 1 |
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| Synonyms: | C-C CKR-1 | C-C chemokine receptor type 1 (CCR1) | CC-CKR-1 | CCR-1 | CCR1 | CCR1_HUMAN | CD_antigen=CD191 | CMKBR1 | CMKR1 | HM145 | LD78 receptor | MIP-1alpha-R | Macrophage inflammatory protein 1-alpha receptor | RANTES-R | SCYAR1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41180.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P32246 |
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| Residue: | 355 |
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| Sequence: | METPNTTEDYDTTTEFDYGDATPCQKVNERAFGAQLLPPLYSLVFVIGLVGNILVVLVLV
QYKRLKNMTSIYLLNLAISDLLFLFTLPFWIDYKLKDDWVFGDAMCKILSGFYYTGLYSE
IFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIIIWALAILASMPGLYFSKTQWEFTH
HTCSLHFPHESLREWKLFQALKLNLFGLVLPLLVMIICYTGIIKILLRRPNEKKSKAVRL
IFVIMIIFFLFWTPYNLTILISVFQDFLFTHECEQSRHLDLAVQVTEVIAYTHCCVNPVI
YAFVGERFRKYLRQLFHRRVAVHLVKWLPFLSVDRLERVSSTSPSTGEHELSAGF
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| BDBM50508183 |
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| n/a |
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| Name | BDBM50508183 |
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| Synonyms: | CHEMBL4562738 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H18FN5O3S |
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| Mol. Mass. | 439.463 |
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| SMILES | CC(NC(=O)c1cncc2n(ncc12)-c1ccc(F)cc1)c1ccnc(c1)S(C)(=O)=O |
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| Structure | 
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