Reaction Details |
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Target | MAP kinase-interacting serine/threonine-protein kinase 1 |
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Ligand | BDBM50510372 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1841473 (CHEMBL4341772) |
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IC50 | 1820±n/a nM |
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Citation | Zhang, M; Jiang, L; Tao, J; Pan, Z; He, M; Su, D; He, G; Jiang, Q Design, synthesis and biological evaluation of 4-aniline-thieno[2,3-d]pyrimidine derivatives as MNK1 inhibitors against renal cell carcinoma and nasopharyngeal carcinoma. Bioorg Med Chem27:2268-2279 (2019) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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MAP kinase-interacting serine/threonine-protein kinase 1 |
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Name: | MAP kinase-interacting serine/threonine-protein kinase 1 |
Synonyms: | MAP Kinase-Interacting Protein Kinase (MNK1) | MAP kinase signal-integrating kinase 1 | MAP kinase-interacting serine/threonine-protein kinase 1 (MnK1) | MAP kinase-interacting serine/threonine-protein kinase MNK1 | MAP-kinase interacting kinase 1 (MNK1) | MAPK signal-integrating kinase 1 | MKNK1 | MKNK1_HUMAN | MNK1 |
Type: | Serine/threonine-protein kinase |
Mol. Mass.: | 51342.85 |
Organism: | Homo sapiens (Human) |
Description: | Q9BUB5 |
Residue: | 465 |
Sequence: | MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAY
AKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRF
YLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPS
GLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMK
LNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPP
FVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAK
QRLSAAQVLQHPWVQGQAPEKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENEL
AEEPEALADGLCSMKLSPPCKSRLARRRALAQAGRGEDRSPPTAL
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BDBM50510372 |
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n/a |
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Name | BDBM50510372 |
Synonyms: | CHEMBL4453419 |
Type | Small organic molecule |
Emp. Form. | C16H15ClN4S |
Mol. Mass. | 330.835 |
SMILES | CN1CCc2c(C1)sc1ncnc(Nc3ccc(Cl)cc3)c21 |
Structure |
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