Ki Summary

Reaction Details

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Target

5-hydroxytryptamine receptor 1B

Ligand

BDBM50005835

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1585 (CHEMBL616996)

6.4±n/a nM

Citation

Ennis, MD; Ghazal, NB; Hoffman, RL; Smith, MW; Schlachter, SK; Lawson, CF; Im, WB; Pregenzer, JF; Svensson, KA; Lewis, RA; Hall, ED; Sutter, DM; Harris, LT; McCall, RB Isochroman-6-carboxamides as highly selective 5-HT1D agonists: potential new treatment for migraine without cardiovascular side effects. J Med Chem41:2180-3 (1998) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

5-hydroxytryptamine receptor 1B

Name:

5-hydroxytryptamine receptor 1B

Synonyms:

5-HT-1B | 5-HT1B | 5HT1B_GORGO | HTR1B | Serotonin receptor 1B

Type:

PROTEIN

Mol. Mass.:

43466.06

Organism:

Gorilla gorilla gorilla

Description:

ChEMBL_105571

Residue:

389

Sequence:

MEEPGAQCAPPPAGSETWVPQANLSSAPSQNCSAKDYIYQDSIALPWKVLLVMLLALITL
ATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVV
CDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISIS
LPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRILK
QTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVYVNQVKVRVSDALLEK
KKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYLN
SLINPIIYTMSNEDFKQAFHKLIRFKCTS

BDBM50005835

n/a

Name

BDBM50005835

Synonyms:

(3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methylmethanesulfonamide | 1-[3-(2-dimethylaminoethyl)-1H-indol-5-yl]-N-methyl-methanesulfonamide | 1-{3-[2-(dimethylamino)ethyl]-1H-indol-5-yl}-N-methylmethanesulfonamide | 3-(2-(dimethylamino)ethyl)-N-methyl-1H-indole-5-methanesulfonamide | 3-[2-(dimethylamino)ethyl]-N-methylindole-5-methanesulfonamide | CHEMBL128 | SUMATRIPTAN | Sumatran | Sumax

Type

Small organic molecule

Emp. Form.

C14H21N3O2S

Mol. Mass.

295.4

SMILES

CNS(=O)(=O)Cc1ccc2[nH]cc(CCN(C)C)c2c1

Structure