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Compile Data Set for Download or QSAR

Found 525 hits with Last Name = 'ghazal' and Initial = 'nb'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50369022
PNG
(CHEMBL1788197)
Show SMILES CCCN(CCCc1ccccc1)[C@@H]1CCc2ccc3[nH]cc(C=O)c3c2C1 |r|
Show InChI InChI=1S/C25H30N2O/c1-2-14-27(15-6-9-19-7-4-3-5-8-19)22-12-10-20-11-13-24-25(23(20)16-22)21(18-28)17-26-24/h3-5,7-8,11,13,17-18,22,26H,2,6,9-10,12,14-16H2,1H3/t22-/m1/s1
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<0.0200n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1A receptor expressed in CHO cells, by using [3H]8-OH-DPAT as radioligand.

J Med Chem 38: 2217-30 (1995)


BindingDB Entry DOI: 10.7270/Q28G8MBW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50035336
PNG
(8-(Phenethyl-propyl-amino)-6,7,8,9-tetrahydro-3H-b...)
Show SMILES CCCN(CCc1ccccc1)C1CCc2ccc3[nH]cc(C=O)c3c2C1
Show InChI InChI=1S/C24H28N2O/c1-2-13-26(14-12-18-6-4-3-5-7-18)21-10-8-19-9-11-23-24(22(19)15-21)20(17-27)16-25-23/h3-7,9,11,16-17,21,25H,2,8,10,12-15H2,1H3
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 0.0400n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1A receptor expressed in CHO cells, by using [3H]8-OH-DPAT as radioligand.

J Med Chem 38: 2217-30 (1995)


BindingDB Entry DOI: 10.7270/Q28G8MBW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50035342
PNG
(8-Pyrrolidin-1-yl-6,7,8,9-tetrahydro-3H-benzo[e]in...)
Show SMILES O=Cc1c[nH]c2ccc3CCC(Cc3c12)N1CCCC1
Show InChI InChI=1S/C17H20N2O/c20-11-13-10-18-16-6-4-12-3-5-14(9-15(12)17(13)16)19-7-1-2-8-19/h4,6,10-11,14,18H,1-3,5,7-9H2
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 0.0700n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1A receptor expressed in CHO cells, by using [3H]8-OH-DPAT as radioligand.

J Med Chem 38: 2217-30 (1995)


BindingDB Entry DOI: 10.7270/Q28G8MBW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50035363
PNG
(8-[Propyl-(2-thiophen-2-yl-ethyl)-amino]-6,7,8,9-t...)
Show SMILES CCCN(CCc1cccs1)C1CCc2ccc3[nH]cc(C=O)c3c2C1
Show InChI InChI=1S/C22H26N2OS/c1-2-10-24(11-9-19-4-3-12-26-19)18-7-5-16-6-8-21-22(20(16)13-18)17(15-25)14-23-21/h3-4,6,8,12,14-15,18,23H,2,5,7,9-11,13H2,1H3
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 0.100n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1A receptor expressed in CHO cells, by using [3H]8-OH-DPAT as radioligand.

J Med Chem 38: 2217-30 (1995)


BindingDB Entry DOI: 10.7270/Q28G8MBW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50035303
PNG
((R)-8-Dipropylamino-6,7,8,9-tetrahydro-3H-benzo[e]...)
Show SMILES CCCN(CCC)[C@@H]1CCc2ccc3[nH]cc(C=O)c3c2C1
Show InChI InChI=1S/C19H26N2O/c1-3-9-21(10-4-2)16-7-5-14-6-8-18-19(17(14)11-16)15(13-22)12-20-18/h6,8,12-13,16,20H,3-5,7,9-11H2,1-2H3/t16-/m1/s1
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 0.200n/an/an/an/an/an/an/an/a



Göteborg University

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor from CHO-K1 cells, using [3H]-8-OH-DPAT as the radioligand.

J Med Chem 38: 2202-16 (1995)


BindingDB Entry DOI: 10.7270/Q24T6HD0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50035305
PNG
((S)-8-Dipropylamino-6,7,8,9-tetrahydro-3H-benzo[e]...)
Show SMILES CCCN(CCC)[C@H]1CCc2ccc3[nH]cc(C=O)c3c2C1
Show InChI InChI=1S/C19H26N2O/c1-3-9-21(10-4-2)16-7-5-14-6-8-18-19(17(14)11-16)15(13-22)12-20-18/h6,8,12-13,16,20H,3-5,7,9-11H2,1-2H3/t16-/m0/s1
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 0.200n/an/an/an/an/an/an/an/a



Göteborg University

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor from CHO-K1 cells, using [3H]-8-OH-DPAT as the radioligand.

J Med Chem 38: 2202-16 (1995)


BindingDB Entry DOI: 10.7270/Q24T6HD0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50369020
PNG
(CHEMBL1788200)
Show SMILES CCCN(CCCCN1C(=O)CC(C)(C)CC1=O)[C@@H]1CCc2ccc3[nH]ccc3c2C1 |r|
Show InChI InChI=1S/C26H37N3O2/c1-4-13-28(14-5-6-15-29-24(30)17-26(2,3)18-25(29)31)20-9-7-19-8-10-23-21(11-12-27-23)22(19)16-20/h8,10-12,20,27H,4-7,9,13-18H2,1-3H3/t20-/m1/s1
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 0.200n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1A receptor expressed in CHO cells, by using [3H]8-OH-DPAT as radioligand.

J Med Chem 38: 2217-30 (1995)


BindingDB Entry DOI: 10.7270/Q28G8MBW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50035303
PNG
((R)-8-Dipropylamino-6,7,8,9-tetrahydro-3H-benzo[e]...)
Show SMILES CCCN(CCC)[C@@H]1CCc2ccc3[nH]cc(C=O)c3c2C1
Show InChI InChI=1S/C19H26N2O/c1-3-9-21(10-4-2)16-7-5-14-6-8-18-19(17(14)11-16)15(13-22)12-20-18/h6,8,12-13,16,20H,3-5,7,9-11H2,1-2H3/t16-/m1/s1
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 0.200n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1A receptor expressed in CHO cells, by using [3H]8-OH-DPAT as radioligand.

J Med Chem 38: 2217-30 (1995)


BindingDB Entry DOI: 10.7270/Q28G8MBW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50035305
PNG
((S)-8-Dipropylamino-6,7,8,9-tetrahydro-3H-benzo[e]...)
Show SMILES CCCN(CCC)[C@H]1CCc2ccc3[nH]cc(C=O)c3c2C1
Show InChI InChI=1S/C19H26N2O/c1-3-9-21(10-4-2)16-7-5-14-6-8-18-19(17(14)11-16)15(13-22)12-20-18/h6,8,12-13,16,20H,3-5,7,9-11H2,1-2H3/t16-/m0/s1
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 0.200n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1A receptor expressed in CHO cells, by using [3H]8-OH-DPAT as radioligand.

J Med Chem 38: 2217-30 (1995)


BindingDB Entry DOI: 10.7270/Q28G8MBW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50035320
PNG
((+/-)-8-Dipropylamino-6,7,8,9-tetrahydro-3H-benzo[...)
Show SMILES CCCN(CCC)C1CCc2ccc3[nH]cc(C=O)c3c2C1
Show InChI InChI=1S/C19H26N2O/c1-3-9-21(10-4-2)16-7-5-14-6-8-18-19(17(14)11-16)15(13-22)12-20-18/h6,8,12-13,16,20H,3-5,7,9-11H2,1-2H3
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 0.200n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1A receptor expressed in CHO cells, by using [3H]8-OH-DPAT as radioligand.

J Med Chem 38: 2217-30 (1995)


BindingDB Entry DOI: 10.7270/Q28G8MBW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (Human))		BDBM50054764
PNG
((E)-3-[3-(2-Dimethylamino-ethyl)-1H-indol-5-yl]-N-...)
Show SMILES COc1ccc(CNC(=O)\C=C\c2ccc3[nH]cc(CCN(C)C)c3c2)cc1
Show InChI InChI=1S/C23H27N3O2/c1-26(2)13-12-19-16-24-22-10-6-17(14-21(19)22)7-11-23(27)25-15-18-4-8-20(28-3)9-5-18/h4-11,14,16,24H,12-13,15H2,1-3H3,(H,25,27)/b11-7+
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 0.200n/an/an/an/an/an/an/an/a



University of Groningen

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor beta expressed in CHO-K1 cells.

J Med Chem 39: 4717-26 (1997)


Article DOI: 10.1021/jm9604890
BindingDB Entry DOI: 10.7270/Q2R210GS
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50035320
PNG
((+/-)-8-Dipropylamino-6,7,8,9-tetrahydro-3H-benzo[...)
Show SMILES CCCN(CCC)C1CCc2ccc3[nH]cc(C=O)c3c2C1
Show InChI InChI=1S/C19H26N2O/c1-3-9-21(10-4-2)16-7-5-14-6-8-18-19(17(14)11-16)15(13-22)12-20-18/h6,8,12-13,16,20H,3-5,7,9-11H2,1-2H3
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 0.200n/an/an/an/an/an/an/an/a



Göteborg University

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor from CHO-K1 cells, using [3H]-8-OH-DPAT as the radioligand.

J Med Chem 38: 2202-16 (1995)


BindingDB Entry DOI: 10.7270/Q24T6HD0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50035366
PNG
(8-Azepan-1-yl-6,7,8,9-tetrahydro-3H-benzo[e]indole...)
Show SMILES O=Cc1c[nH]c2ccc3CCC(Cc3c12)N1CCCCCC1
Show InChI InChI=1S/C19H24N2O/c22-13-15-12-20-18-8-6-14-5-7-16(11-17(14)19(15)18)21-9-3-1-2-4-10-21/h6,8,12-13,16,20H,1-5,7,9-11H2
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 0.240n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1A receptor expressed in CHO cells, by using [3H]8-OH-DPAT as radioligand.

J Med Chem 38: 2217-30 (1995)


BindingDB Entry DOI: 10.7270/Q28G8MBW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50035335
PNG
((R)-8-Dipropylamino-4-fluoro-6,7,8,9-tetrahydro-3H...)
Show SMILES CCCN(CCC)[C@@H]1CCc2cc(F)c3[nH]cc(C=O)c3c2C1
Show InChI InChI=1S/C19H25FN2O/c1-3-7-22(8-4-2)15-6-5-13-9-17(20)19-18(16(13)10-15)14(12-23)11-21-19/h9,11-12,15,21H,3-8,10H2,1-2H3/t15-/m1/s1
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 0.300n/an/an/an/an/an/an/an/a



Göteborg University

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor from CHO-K1 cells, using [3H]-8-OH-DPAT as the radioligand.

J Med Chem 38: 2202-16 (1995)


BindingDB Entry DOI: 10.7270/Q24T6HD0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50035347
PNG
(8-(Allyl-propyl-amino)-6,7,8,9-tetrahydro-3H-benzo...)
Show SMILES CCCN(CC=C)C1CCc2ccc3[nH]cc(C=O)c3c2C1
Show InChI InChI=1S/C19H24N2O/c1-3-9-21(10-4-2)16-7-5-14-6-8-18-19(17(14)11-16)15(13-22)12-20-18/h3,6,8,12-13,16,20H,1,4-5,7,9-11H2,2H3
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 0.300n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1A receptor expressed in CHO cells, by using [3H]8-OH-DPAT as radioligand.

J Med Chem 38: 2217-30 (1995)


BindingDB Entry DOI: 10.7270/Q28G8MBW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))		BDBM50054764
PNG
((E)-3-[3-(2-Dimethylamino-ethyl)-1H-indol-5-yl]-N-...)
Show SMILES COc1ccc(CNC(=O)\C=C\c2ccc3[nH]cc(CCN(C)C)c3c2)cc1
Show InChI InChI=1S/C23H27N3O2/c1-26(2)13-12-19-16-24-22-10-6-17(14-21(19)22)7-11-23(27)25-15-18-4-8-20(28-3)9-5-18/h4-11,14,16,24H,12-13,15H2,1-3H3,(H,25,27)/b11-7+
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 0.300n/an/an/an/an/an/an/an/a



University of Groningen

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.

J Med Chem 39: 4717-26 (1997)


Article DOI: 10.1021/jm9604890
BindingDB Entry DOI: 10.7270/Q2R210GS
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50035326
PNG
(8-Dipropylamino-6,7,8,9-tetrahydro-3H-benzo[e]indo...)
Show SMILES CCCN(CCC)C1CCc2ccc3[nH]cc(C#N)c3c2C1
Show InChI InChI=1S/C19H25N3/c1-3-9-22(10-4-2)16-7-5-14-6-8-18-19(17(14)11-16)15(12-20)13-21-18/h6,8,13,16,21H,3-5,7,9-11H2,1-2H3
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 0.400n/an/an/an/an/an/an/an/a



Göteborg University

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor from CHO-K1 cells, using [3H]-8-OH-DPAT as the radioligand.

J Med Chem 38: 2202-16 (1995)


BindingDB Entry DOI: 10.7270/Q24T6HD0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM21393
PNG
(7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-o...)
Show SMILES CCCN(CCC)C1CCc2cccc(O)c2C1
Show InChI InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3
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 0.5n/an/an/an/an/an/an/an/a



Göteborg University

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor from CHO-K1 cells, using [3H]-8-OH-DPAT as the radioligand.

J Med Chem 38: 2202-16 (1995)


BindingDB Entry DOI: 10.7270/Q24T6HD0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50035324
PNG
((S)-8-Dipropylamino-6,7,8,9-tetrahydro-3H-benzo[e]...)
Show SMILES CCCN(CCC)[C@H]1CCc2ccc3[nH]cc(C#N)c3c2C1
Show InChI InChI=1S/C19H25N3/c1-3-9-22(10-4-2)16-7-5-14-6-8-18-19(17(14)11-16)15(12-20)13-21-18/h6,8,13,16,21H,3-5,7,9-11H2,1-2H3/t16-/m0/s1
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 0.5n/an/an/an/an/an/an/an/a



Göteborg University

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor from CHO-K1 cells, using [3H]-8-OH-DPAT as the radioligand.

J Med Chem 38: 2202-16 (1995)


BindingDB Entry DOI: 10.7270/Q24T6HD0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50035319
PNG
(8-Dipropylamino-4-fluoro-6,7,8,9-tetrahydro-3H-ben...)
Show SMILES CCCN(CCC)C1CCc2cc(F)c3[nH]cc(C=O)c3c2C1
Show InChI InChI=1S/C19H25FN2O/c1-3-7-22(8-4-2)15-6-5-13-9-17(20)19-18(16(13)10-15)14(12-23)11-21-19/h9,11-12,15,21H,3-8,10H2,1-2H3
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 0.5n/an/an/an/an/an/an/an/a



Göteborg University

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor from CHO-K1 cells, using [3H]-8-OH-DPAT as the radioligand.

J Med Chem 38: 2202-16 (1995)


BindingDB Entry DOI: 10.7270/Q24T6HD0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50035345
PNG
(CHEMBL71145 | Propyl-(6,7,8,9-tetrahydro-3H-benzo[...)
Show SMILES CCCN(CCc1cccs1)C1CCc2ccc3[nH]ccc3c2C1
Show InChI InChI=1S/C21H26N2S/c1-2-12-23(13-10-18-4-3-14-24-18)17-7-5-16-6-8-21-19(9-11-22-21)20(16)15-17/h3-4,6,8-9,11,14,17,22H,2,5,7,10,12-13,15H2,1H3
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 0.600n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1A receptor expressed in CHO cells, by using [3H]8-OH-DPAT as radioligand.

J Med Chem 38: 2217-30 (1995)


BindingDB Entry DOI: 10.7270/Q28G8MBW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50035353
PNG
(8-(Cyclopropylmethyl-propyl-amino)-6,7,8,9-tetrahy...)
Show SMILES CCCN(CC1CC1)C1CCc2ccc3[nH]cc(C=O)c3c2C1
Show InChI InChI=1S/C20H26N2O/c1-2-9-22(12-14-3-4-14)17-7-5-15-6-8-19-20(18(15)10-17)16(13-23)11-21-19/h6,8,11,13-14,17,21H,2-5,7,9-10,12H2,1H3
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 0.600n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1A receptor expressed in CHO cells, by using [3H]8-OH-DPAT as radioligand.

J Med Chem 38: 2217-30 (1995)


BindingDB Entry DOI: 10.7270/Q28G8MBW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50369016
PNG
(CHEMBL1788198)
Show SMILES CCCN(CCCCN1C(=O)CC(C)(C)CC1=O)[C@@H]1CCc2ccc3[nH]cc(C=O)c3c2C1 |r|
Show InChI InChI=1S/C27H37N3O3/c1-4-11-29(12-5-6-13-30-24(32)15-27(2,3)16-25(30)33)21-9-7-19-8-10-23-26(22(19)14-21)20(18-31)17-28-23/h8,10,17-18,21,28H,4-7,9,11-16H2,1-3H3/t21-/m1/s1
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 0.600n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1A receptor expressed in CHO cells, by using [3H]8-OH-DPAT as radioligand.

J Med Chem 38: 2217-30 (1995)


BindingDB Entry DOI: 10.7270/Q28G8MBW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50035359
PNG
(8-[(3-Phenyl-propyl)-propyl-amino]-6,7,8,9-tetrahy...)
Show SMILES CCCN(CCCc1ccccc1)C1CCc2ccc3[nH]cc(C=O)c3c2C1
Show InChI InChI=1S/C25H30N2O/c1-2-14-27(15-6-9-19-7-4-3-5-8-19)22-12-10-20-11-13-24-25(23(20)16-22)21(18-28)17-26-24/h3-5,7-8,11,13,17-18,22,26H,2,6,9-10,12,14-16H2,1H3
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 0.600n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1A receptor expressed in CHO cells, by using [3H]8-OH-DPAT as radioligand.

J Med Chem 38: 2217-30 (1995)


BindingDB Entry DOI: 10.7270/Q28G8MBW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50035350
PNG
(8-(Methyl-propyl-amino)-6,7,8,9-tetrahydro-3H-benz...)
Show SMILES CCCN(C)C1CCc2ccc3[nH]cc(C=O)c3c2C1
Show InChI InChI=1S/C17H22N2O/c1-3-8-19(2)14-6-4-12-5-7-16-17(15(12)9-14)13(11-20)10-18-16/h5,7,10-11,14,18H,3-4,6,8-9H2,1-2H3
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 0.700n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1A receptor expressed in CHO cells, by using [3H]8-OH-DPAT as radioligand.

J Med Chem 38: 2217-30 (1995)


BindingDB Entry DOI: 10.7270/Q28G8MBW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50035351
PNG
(CHEMBL72285 | Phenethyl-propyl-(6,7,8,9-tetrahydro...)
Show SMILES CCCN(CCc1ccccc1)C1CCc2ccc3[nH]ccc3c2C1
Show InChI InChI=1S/C23H28N2/c1-2-15-25(16-13-18-6-4-3-5-7-18)20-10-8-19-9-11-23-21(12-14-24-23)22(19)17-20/h3-7,9,11-12,14,20,24H,2,8,10,13,15-17H2,1H3
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 0.700n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1A receptor expressed in CHO cells, by using [3H]8-OH-DPAT as radioligand.

J Med Chem 38: 2217-30 (1995)


BindingDB Entry DOI: 10.7270/Q28G8MBW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50035365
PNG
(8-Pyrrolidin-1-yl-6,7,8,9-tetrahydro-3H-benzo[e]in...)
Show SMILES C1CCN(C1)C1CCc2ccc3[nH]ccc3c2C1
Show InChI InChI=1S/C16H20N2/c1-2-10-18(9-1)13-5-3-12-4-6-16-14(7-8-17-16)15(12)11-13/h4,6-8,13,17H,1-3,5,9-11H2
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 0.800n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1A receptor expressed in CHO cells, by using [3H]8-OH-DPAT as radioligand.

J Med Chem 38: 2217-30 (1995)


BindingDB Entry DOI: 10.7270/Q28G8MBW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50035343
PNG
(8-{[3-(3-Chloro-phenoxy)-propyl]-propyl-amino}-6,7...)
Show SMILES CCCN(CCCOc1cccc(Cl)c1)C1CCc2ccc3[nH]cc(C=O)c3c2C1
Show InChI InChI=1S/C25H29ClN2O2/c1-2-11-28(12-4-13-30-22-6-3-5-20(26)14-22)21-9-7-18-8-10-24-25(23(18)15-21)19(17-29)16-27-24/h3,5-6,8,10,14,16-17,21,27H,2,4,7,9,11-13,15H2,1H3
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 0.800n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1A receptor expressed in CHO cells, by using [3H]8-OH-DPAT as radioligand.

J Med Chem 38: 2217-30 (1995)


BindingDB Entry DOI: 10.7270/Q28G8MBW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50035315
PNG
((S)-8-Dipropylamino-4-fluoro-6,7,8,9-tetrahydro-3H...)
Show SMILES CCCN(CCC)[C@H]1CCc2cc(F)c3[nH]cc(C=O)c3c2C1
Show InChI InChI=1S/C19H25FN2O/c1-3-7-22(8-4-2)15-6-5-13-9-17(20)19-18(16(13)10-15)14(12-23)11-21-19/h9,11-12,15,21H,3-8,10H2,1-2H3/t15-/m0/s1
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 0.800n/an/an/an/an/an/an/an/a



Göteborg University

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor from CHO-K1 cells, using [3H]-8-OH-DPAT as the radioligand.

J Med Chem 38: 2202-16 (1995)


BindingDB Entry DOI: 10.7270/Q24T6HD0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50035328
PNG
((R)-8-Dipropylamino-6,7,8,9-tetrahydro-3H-benzo[e]...)
Show SMILES CCCN(CCC)[C@@H]1CCc2ccc3[nH]cc(C#N)c3c2C1
Show InChI InChI=1S/C19H25N3/c1-3-9-22(10-4-2)16-7-5-14-6-8-18-19(17(14)11-16)15(12-20)13-21-18/h6,8,13,16,21H,3-5,7,9-11H2,1-2H3/t16-/m1/s1
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 0.800n/an/an/an/an/an/an/an/a



Göteborg University

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor from CHO-K1 cells, using [3H]-8-OH-DPAT as the radioligand.

J Med Chem 38: 2202-16 (1995)


BindingDB Entry DOI: 10.7270/Q24T6HD0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))		BDBM50064786
PNG
((S)-1-(2-(4-(4-methoxyphenyl)piperazin-1-yl)ethyl)...)
Show SMILES CNC(=O)c1ccc2[C@H](CCN3CCN(CC3)c3ccc(OC)cc3)OCCc2c1 |r|
Show InChI InChI=1S/C24H31N3O3/c1-25-24(28)19-3-8-22-18(17-19)10-16-30-23(22)9-11-26-12-14-27(15-13-26)20-4-6-21(29-2)7-5-20/h3-8,17,23H,9-16H2,1-2H3,(H,25,28)/t23-/m0/s1
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 0.900n/an/an/an/an/an/an/an/a



Pharmacia & Upjohn

Curated by ChEMBL


Assay Description
The compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1D receptor from cloned gorilla membranes expressed in cultured HEK 293 ...

J Med Chem 41: 2180-3 (1998)


Article DOI: 10.1021/jm980137o
BindingDB Entry DOI: 10.7270/Q2NV9HCP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))		BDBM50369022
PNG
(CHEMBL1788197)
Show SMILES CCCN(CCCc1ccccc1)[C@@H]1CCc2ccc3[nH]cc(C=O)c3c2C1 |r|
Show InChI InChI=1S/C25H30N2O/c1-2-14-27(15-6-9-19-7-4-3-5-8-19)22-12-10-20-11-13-24-25(23(20)16-22)21(18-28)17-26-24/h3-5,7-8,11,13,17-18,22,26H,2,6,9-10,12,14-16H2,1H3/t22-/m1/s1
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 0.900n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand

J Med Chem 38: 2217-30 (1995)


BindingDB Entry DOI: 10.7270/Q28G8MBW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50035356
PNG
(8-Propylamino-6,7,8,9-tetrahydro-3H-benzo[e]indole...)
Show SMILES CCCNC1CCc2ccc3[nH]cc(C=O)c3c2C1
Show InChI InChI=1S/C16H20N2O/c1-2-7-17-13-5-3-11-4-6-15-16(14(11)8-13)12(10-19)9-18-15/h4,6,9-10,13,17-18H,2-3,5,7-8H2,1H3
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 1n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1A receptor expressed in CHO cells, by using [3H]8-OH-DPAT as radioligand.

J Med Chem 38: 2217-30 (1995)


BindingDB Entry DOI: 10.7270/Q28G8MBW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50369017
PNG
(CHEMBL1744039)
Show SMILES CCCN(CC(C)C)[C@@H]1CCc2ccc3[nH]cc(C=O)c3c2C1 |r|
Show InChI InChI=1S/C20H28N2O/c1-4-9-22(12-14(2)3)17-7-5-15-6-8-19-20(18(15)10-17)16(13-23)11-21-19/h6,8,11,13-14,17,21H,4-5,7,9-10,12H2,1-3H3/t17-/m1/s1
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 1.10n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1A receptor expressed in CHO cells, by using [3H]8-OH-DPAT as radioligand.

J Med Chem 38: 2217-30 (1995)


BindingDB Entry DOI: 10.7270/Q28G8MBW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50035360
PNG
(8-{[3-(2-Methoxy-phenyl)-propyl]-propyl-amino}-6,7...)
Show SMILES CCCN(CCCc1ccccc1OC)C1CCc2ccc3[nH]cc(C=O)c3c2C1
Show InChI InChI=1S/C26H32N2O2/c1-3-14-28(15-6-8-20-7-4-5-9-25(20)30-2)22-12-10-19-11-13-24-26(23(19)16-22)21(18-29)17-27-24/h4-5,7,9,11,13,17-18,22,27H,3,6,8,10,12,14-16H2,1-2H3
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 1.20n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1A receptor expressed in CHO cells, by using [3H]8-OH-DPAT as radioligand.

J Med Chem 38: 2217-30 (1995)


BindingDB Entry DOI: 10.7270/Q28G8MBW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))		BDBM50054764
PNG
((E)-3-[3-(2-Dimethylamino-ethyl)-1H-indol-5-yl]-N-...)
Show SMILES COc1ccc(CNC(=O)\C=C\c2ccc3[nH]cc(CCN(C)C)c3c2)cc1
Show InChI InChI=1S/C23H27N3O2/c1-26(2)13-12-19-16-24-22-10-6-17(14-21(19)22)7-11-23(27)25-15-18-4-8-20(28-3)9-5-18/h4-11,14,16,24H,12-13,15H2,1-3H3,(H,25,27)/b11-7+
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 1.30n/an/an/an/an/an/an/an/a



University of Groningen

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1A receptor expressed in CHO-K1 cells.

J Med Chem 39: 4717-26 (1997)


Article DOI: 10.1021/jm9604890
BindingDB Entry DOI: 10.7270/Q2R210GS
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50035307
PNG
(CHEMBL302171 | Dipropyl-(S)-6,7,8,9-tetrahydro-3H-...)
Show SMILES CCCN(CCC)[C@H]1CCc2ccc3[nH]ccc3c2C1
Show InChI InChI=1S/C18H26N2/c1-3-11-20(12-4-2)15-7-5-14-6-8-18-16(9-10-19-18)17(14)13-15/h6,8-10,15,19H,3-5,7,11-13H2,1-2H3/t15-/m0/s1
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 1.40n/an/an/an/an/an/an/an/a



Göteborg University

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor from CHO-K1 cells, using [3H]-8-OH-DPAT as the radioligand.

J Med Chem 38: 2202-16 (1995)


BindingDB Entry DOI: 10.7270/Q24T6HD0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50035304
PNG
((4-Fluoro-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-yl...)
Show SMILES CCCN(CCC)C1CCc2cc(F)c3[nH]ccc3c2C1
Show InChI InChI=1S/C18H25FN2/c1-3-9-21(10-4-2)14-6-5-13-11-17(19)18-15(7-8-20-18)16(13)12-14/h7-8,11,14,20H,3-6,9-10,12H2,1-2H3
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 1.40n/an/an/an/an/an/an/an/a



Göteborg University

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor from CHO-K1 cells, using [3H]-8-OH-DPAT as the radioligand.

J Med Chem 38: 2202-16 (1995)


BindingDB Entry DOI: 10.7270/Q24T6HD0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50035307
PNG
(CHEMBL302171 | Dipropyl-(S)-6,7,8,9-tetrahydro-3H-...)
Show SMILES CCCN(CCC)[C@H]1CCc2ccc3[nH]ccc3c2C1
Show InChI InChI=1S/C18H26N2/c1-3-11-20(12-4-2)15-7-5-14-6-8-18-16(9-10-19-18)17(14)13-15/h6,8-10,15,19H,3-5,7,11-13H2,1-2H3/t15-/m0/s1
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 1.40n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1A receptor expressed in CHO cells, by using [3H]8-OH-DPAT as radioligand.

J Med Chem 38: 2217-30 (1995)


BindingDB Entry DOI: 10.7270/Q28G8MBW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50453697
PNG
(CHEMBL2112317)
Show SMILES O.CCCN(CCCCN1C(=O)CC(C)(C)CC1=O)[C@H]1CCc2ccc3[nH]cc(C=O)c3c2C1 |r|
Show InChI InChI=1S/C27H37N3O3.H2O/c1-4-11-29(12-5-6-13-30-24(32)15-27(2,3)16-25(30)33)21-9-7-19-8-10-23-26(22(19)14-21)20(18-31)17-28-23;/h8,10,17-18,21,28H,4-7,9,11-16H2,1-3H3;1H2/t21-;/m0./s1
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 1.5n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1A receptor expressed in CHO cells, by using [3H]8-OH-DPAT as radioligand.

J Med Chem 38: 2217-30 (1995)


BindingDB Entry DOI: 10.7270/Q28G8MBW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50369019
PNG
(CHEMBL1744040)
Show SMILES CN(C)[C@@H]1CCc2ccc3[nH]cc(C=O)c3c2C1 |r|
Show InChI InChI=1S/C15H18N2O/c1-17(2)12-5-3-10-4-6-14-15(13(10)7-12)11(9-18)8-16-14/h4,6,8-9,12,16H,3,5,7H2,1-2H3/t12-/m1/s1
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 1.5n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1A receptor expressed in CHO cells, by using [3H]8-OH-DPAT as radioligand.

J Med Chem 38: 2217-30 (1995)


BindingDB Entry DOI: 10.7270/Q28G8MBW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50035317
PNG
(((R)-4-Fluoro-6,7,8,9-tetrahydro-3H-benzo[e]indol-...)
Show SMILES CCCN(CCC)[C@@H]1CCc2cc(F)c3[nH]ccc3c2C1
Show InChI InChI=1S/C18H25FN2/c1-3-9-21(10-4-2)14-6-5-13-11-17(19)18-15(7-8-20-18)16(13)12-14/h7-8,11,14,20H,3-6,9-10,12H2,1-2H3/t14-/m1/s1
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 1.5n/an/an/an/an/an/an/an/a



Göteborg University

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor from CHO-K1 cells, using [3H]-8-OH-DPAT as the radioligand.

J Med Chem 38: 2202-16 (1995)


BindingDB Entry DOI: 10.7270/Q24T6HD0
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Rattus norvegicus (Rat))		BDBM50035304
PNG
((4-Fluoro-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-yl...)
Show SMILES CCCN(CCC)C1CCc2cc(F)c3[nH]ccc3c2C1
Show InChI InChI=1S/C18H25FN2/c1-3-9-21(10-4-2)14-6-5-13-11-17(19)18-15(7-8-20-18)16(13)12-14/h7-8,11,14,20H,3-6,9-10,12H2,1-2H3
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 1.60n/an/an/an/an/an/an/an/a



Göteborg University

Curated by ChEMBL


Assay Description
Binding affinity against Dopamine receptor D3 from CHO-K1 cells, using [3H]-spiperone as the radioligand.

J Med Chem 38: 2202-16 (1995)


BindingDB Entry DOI: 10.7270/Q24T6HD0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))		BDBM50369019
PNG
(CHEMBL1744040)
Show SMILES CN(C)[C@@H]1CCc2ccc3[nH]cc(C=O)c3c2C1 |r|
Show InChI InChI=1S/C15H18N2O/c1-17(2)12-5-3-10-4-6-14-15(13(10)7-12)11(9-18)8-16-14/h4,6,8-9,12,16H,3,5,7H2,1-2H3/t12-/m1/s1
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 1.60n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand

J Med Chem 38: 2217-30 (1995)


BindingDB Entry DOI: 10.7270/Q28G8MBW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50035352
PNG
(4,4-Dimethyl-1-{4-[propyl-(6,7,8,9-tetrahydro-3H-b...)
Show SMILES CCCN(CCCCN1C(=O)CC(C)(C)CC1=O)C1CCc2ccc3[nH]ccc3c2C1
Show InChI InChI=1S/C26H37N3O2/c1-4-13-28(14-5-6-15-29-24(30)17-26(2,3)18-25(29)31)20-9-7-19-8-10-23-21(11-12-27-23)22(19)16-20/h8,10-12,20,27H,4-7,9,13-18H2,1-3H3
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 1.90n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1A receptor expressed in CHO cells, by using [3H]8-OH-DPAT as radioligand.

J Med Chem 38: 2217-30 (1995)


BindingDB Entry DOI: 10.7270/Q28G8MBW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50035341
PNG
(Benzyl-propyl-(6,7,8,9-tetrahydro-3H-benzo[e]indol...)
Show SMILES CCCN(Cc1ccccc1)C1CCc2ccc3[nH]ccc3c2C1
Show InChI InChI=1S/C22H26N2/c1-2-14-24(16-17-6-4-3-5-7-17)19-10-8-18-9-11-22-20(12-13-23-22)21(18)15-19/h3-7,9,11-13,19,23H,2,8,10,14-16H2,1H3
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 1.90n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1A receptor expressed in CHO cells, by using [3H]8-OH-DPAT as radioligand.

J Med Chem 38: 2217-30 (1995)


BindingDB Entry DOI: 10.7270/Q28G8MBW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))		BDBM50035359
PNG
(8-[(3-Phenyl-propyl)-propyl-amino]-6,7,8,9-tetrahy...)
Show SMILES CCCN(CCCc1ccccc1)C1CCc2ccc3[nH]cc(C=O)c3c2C1
Show InChI InChI=1S/C25H30N2O/c1-2-14-27(15-6-9-19-7-4-3-5-8-19)22-12-10-20-11-13-24-25(23(20)16-22)21(18-28)17-26-24/h3-5,7-8,11,13,17-18,22,26H,2,6,9-10,12,14-16H2,1H3
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 2n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand

J Med Chem 38: 2217-30 (1995)


BindingDB Entry DOI: 10.7270/Q28G8MBW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))		BDBM50035363
PNG
(8-[Propyl-(2-thiophen-2-yl-ethyl)-amino]-6,7,8,9-t...)
Show SMILES CCCN(CCc1cccs1)C1CCc2ccc3[nH]cc(C=O)c3c2C1
Show InChI InChI=1S/C22H26N2OS/c1-2-10-24(11-9-19-4-3-12-26-19)18-7-5-16-6-8-21-22(20(16)13-18)17(15-25)14-23-21/h3-4,6,8,12,14-15,18,23H,2,5,7,9-11,13H2,1H3
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 2n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand

J Med Chem 38: 2217-30 (1995)


BindingDB Entry DOI: 10.7270/Q28G8MBW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))		BDBM50005835
PNG
((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Show SMILES CNS(=O)(=O)Cc1ccc2[nH]cc(CCN(C)C)c2c1
Show InChI InChI=1S/C14H21N3O2S/c1-15-20(18,19)10-11-4-5-14-13(8-11)12(9-16-14)6-7-17(2)3/h4-5,8-9,15-16H,6-7,10H2,1-3H3
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 2n/an/an/an/an/an/an/an/a



Pharmacia & Upjohn

Curated by ChEMBL


Assay Description
The compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1D receptor from cloned gorilla membranes expressed in cultured HEK 293 ...

J Med Chem 41: 2180-3 (1998)


Article DOI: 10.1021/jm980137o
BindingDB Entry DOI: 10.7270/Q2NV9HCP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50035306
PNG
((1-Chloro-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-yl...)
Show SMILES CCCN(CCC)C1CCc2ccc3[nH]cc(Cl)c3c2C1
Show InChI InChI=1S/C18H25ClN2/c1-3-9-21(10-4-2)14-7-5-13-6-8-17-18(15(13)11-14)16(19)12-20-17/h6,8,12,14,20H,3-5,7,9-11H2,1-2H3
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 2n/an/an/an/an/an/an/an/a



Göteborg University

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor from CHO-K1 cells, using [3H]-8-OH-DPAT as the radioligand.

J Med Chem 38: 2202-16 (1995)


BindingDB Entry DOI: 10.7270/Q24T6HD0
More data for this
Ligand-Target Pair
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