| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin B |
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| Ligand | BDBM20096 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1842106 (CHEMBL4342533) |
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| IC50 | 62000±n/a nM |
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| Citation |  Schmitz, J; Gilberg, E; Löser, R; Bajorath, J; Bartz, U; Gütschow, M Cathepsin B: Active site mapping with peptidic substrates and inhibitors. Bioorg Med Chem27:1-15 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cathepsin B |
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| Name: | Cathepsin B |
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| Synonyms: | APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 37819.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_63102437 |
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| Residue: | 339 |
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| Sequence: | MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCG
TFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDR
ICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCR
PYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIM
AEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSW
NTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
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| BDBM20096 |
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| n/a |
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| Name | BDBM20096 |
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| Synonyms: | CHEMBL344174 | benzyl N-[(1S)-1-[(cyanomethyl)carbamoyl]-2-phenylethyl]carbamate | dipeptide-derived nitrile, 17 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H19N3O3 |
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| Mol. Mass. | 337.3725 |
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| SMILES | O=C(N[C@@H](Cc1ccccc1)C(=O)NCC#N)OCc1ccccc1 |r| |
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| Structure | 
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