| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase B-raf |
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| Ligand | BDBM88120 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1842510 (CHEMBL4342937) |
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| Kd | 1.3±n/a nM |
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| Citation |  Ramurthy, S; Taft, BR; Aversa, RJ; Barsanti, PA; Burger, MT; Lou, Y; Nishiguchi, GA; Rico, A; Setti, L; Smith, A; Subramanian, S; Tamez, V; Tanner, H; Wan, L; Hu, C; Appleton, BA; Mamo, M; Tandeske, L; Tellew, JE; Huang, S; Yue, Q; Chaudhary, A; Tian, H; Iyer, R; Hassan, AQ; Mathews Griner, LA; La Bonte, LR; Cooke, VG; Van Abbema, A; Merritt, H; Gampa, K; Feng, F; Yuan, J; Mishina, Y; Wang, Y; Haling, JR; Vaziri, S; Hekmat-Nejad, M; Polyakov, V; Zang, R; Sethuraman, V; Amiri, P; Singh, M; Sellers, WR; Lees, E; Shao, W; Dillon, MP; Stuart, DD Design and Discovery of J Med Chem63:2013-2027 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase B-raf |
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| Name: | Serine/threonine-protein kinase B-raf |
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| Synonyms: | B-RAF | B-Raf Protein Kinase | B-Raf proto-oncogene serine/threonine-protein kinase | BRAF | BRAF1 | BRAF_HUMAN | RAFB1 | p94 | v-Raf murine sarcoma viral oncogene homolog B1 |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 84446.00 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P15056 |
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| Residue: | 766 |
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| Sequence: | MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEH
IEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTV
TSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS
LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRK
TFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPI
PQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQR
DRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSP
GPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDV
AVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHH
LHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATV
KSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNIN
NRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARS
LPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
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| BDBM88120 |
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| n/a |
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| Name | BDBM88120 |
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| Synonyms: | US10245267, Example 1156 | US10709712, Example 1156 | US9694016, 1156 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H25F3N4O4 |
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| Mol. Mass. | 502.4856 |
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| SMILES | Cc1ccc(NC(=O)c2ccnc(c2)C(F)(F)F)cc1-c1cc(OCCO)nc(c1)N1CCOCC1 |
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| Structure | 
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