| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Glycogen phosphorylase, liver form |
|---|
| Ligand | BDBM35346 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_99040 (CHEMBL712593) |
|---|
| IC50 | 205±n/a nM |
|---|
| Citation |  Hoover, DJ; Lefkowitz-Snow, S; Burgess-Henry, JL; Martin, WH; Armento, SJ; Stock, IA; McPherson, RK; Genereux, PE; Gibbs, EM; Treadway, JL Indole-2-carboxamide inhibitors of human liver glycogen phosphorylase. J Med Chem41:2934-8 (1998) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Glycogen phosphorylase, liver form |
|---|
| Name: | Glycogen phosphorylase, liver form |
|---|
| Synonyms: | Glycogen Phosphorylase (PYGL) | Glycogen Phosphorylase, liver form | Liver glycogen phosphorylase | PYGL | PYGL_HUMAN |
|---|
| Type: | Homodimer |
|---|
| Mol. Mass.: | 97153.98 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Dimers associate into a tetramer to form the enzymatically active phosphorylase A. |
|---|
| Residue: | 847 |
|---|
| Sequence: | MAKPLTDQEKRRQISIRGIVGVENVAELKKSFNRHLHFTLVKDRNVATTRDYYFALAHTV
RDHLVGRWIRTQQHYYDKCPKRVYYLSLEFYMGRTLQNTMINLGLQNACDEAIYQLGLDI
EELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEYGIFNQKIRDGWQVEEA
DDWLRYGNPWEKSRPEFMLPVHFYGKVEHTNTGTKWIDTQVVLALPYDTPVPGYMNNTVN
TMRLWSARAPNDFNLRDFNVGDYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFV
VAATLQDIIRRFKASKFGSTRGAGTVFDAFPDQVAIQLNDTHPALAIPELMRIFVDIEKL
PWSKAWELTQKTFAYTNHTVLPEALERWPVDLVEKLLPRHLEIIYEINQKHLDRIVALFP
KDVDRLRRMSLIEEEGSKRINMAHLCIVGSHAVNGVAKIHSDIVKTKVFKDFSELEPDKF
QNKTNGITPRRWLLLCNPGLAELIAEKIGEDYVKDLSQLTKLHSFLGDDVFLRELAKVKQ
ENKLKFSQFLETEYKVKINPSSMFDVQVKRIHEYKRQLLNCLHVITMYNRIKKDPKKLFV
PRTVIIGGKAAPGYHMAKMIIKLITSVADVVNNDPMVGSKLKVIFLENYRVSLAEKVIPA
TDLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENLFIFGMRIDDVA
ALDKKGYEAKEYYEALPELKLVIDQIDNGFFSPKQPDLFKDIINMLFYHDRFKVFADYEA
YVKCQDKVSQLYMNPKAWNTMVLKNIAASGKFSSDRTIKEYAQNIWNVEPSDLKISLSNE
SNKVNGN
|
|
|
|---|
| BDBM35346 |
|---|
| n/a |
|---|
| Name | BDBM35346 |
|---|
| Synonyms: | (S)-5-chloro-N-(3-(4-fluorophenyl)-1-(4-hydroxypiperidin-1-yl)-1-oxopropan-2-yl)-1H-indole-2-carboxamide | 5-CHLORO-1H-INDOLE-2-CARBOXYLIC ACID [1-(4-FLUOROBENZYL)-2-(4-HYDROXYPIPERIDIN-1YL)-2-OXOETHYL]AMIDE | 5-Chloro-1H-indole-2-carboxylic acid [(S)-1-(4-fluoro-benzyl)-2-(4-hydroxy-piperidin-1-yl)-2-oxo-ethyl]-amide | CHEMBL99889 | CP-320626 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H23ClFN3O3 |
|---|
| Mol. Mass. | 443.898 |
|---|
| SMILES | OC1CCN(CC1)C(=O)[C@H](Cc1ccc(F)cc1)NC(=O)c1cc2cc(Cl)ccc2[nH]1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
