Reaction Details |
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Target | Chymotrypsinogen A |
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Ligand | BDBM50066998 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_49929 (CHEMBL660312) |
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IC50 | 4000±n/a nM |
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Citation | Macdonald, SJ; Belton, DJ; Buckley, DM; Spooner, JE; Anson, MS; Harrison, LA; Mills, K; Upton, RJ; Dowle, MD; Smith, RA; Molloy, CR; Risley, C Syntheses of trans-5-oxo-hexahydro-pyrrolo[3,2-b]pyrroles and trans-5-oxo-hexahydro-furo[3,2-b]pyrroles (pyrrolidine trans-lactams and trans-lactones): new pharmacophores for elastase inhibition. J Med Chem41:3919-22 (1998) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Chymotrypsinogen A |
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Name: | Chymotrypsinogen A |
Synonyms: | Alpha-chymotrypsin | CTRA_BOVIN | Chymotrypsin A | Chymotrypsin A chain A | Chymotrypsin A chain B | Chymotrypsin A chain C | Chymotrypsinogen A | alpha-Chymotrypsin (α-Chymotrypsin) |
Type: | Serine protease |
Mol. Mass.: | 25670.88 |
Organism: | Bos taurus (bovine) |
Description: | n/a |
Residue: | 245 |
Sequence: | CGVPAIQPVLSGLSRIVNGEEAVPGSWPWQVSLQDKTGFHFCGGSLINENWVVTAAHCGV
TTSDVVVAGEFDQGSSSEKIQKLKIAKVFKNSKYNSLTINNDITLLKLSTAASFSQTVSA
VCLPSASDDFAAGTTCVTTGWGLTRYTNANTPDRLQQASLPLLSNTNCKKYWGTKIKDAM
ICAGASGVSSCMGDSGGPLVCKKNGAWTLVGIVSWGSSTCSTSTPGVYARVTALVNWVQQ
TLAAN
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BDBM50066998 |
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n/a |
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Name | BDBM50066998 |
Synonyms: | (3R,6aS)-3-Allyl-2-oxo-hexahydro-furo[3,2-b]pyrrole-4-carboxylic acid ethyl ester | CHEMBL127027 |
Type | Small organic molecule |
Emp. Form. | C12H17NO4 |
Mol. Mass. | 239.2677 |
SMILES | CCOC(=O)N1CC[C@@H]2OC(=O)[C@H](CC=C)C12 |
Structure |
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