| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-lactamase |
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| Ligand | BDBM50067052 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_40704 (CHEMBL654916) |
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| IC50 | >100000±n/a nM |
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| Citation |  Heinze-Krauss, I; Angehrn, P; Charnas, RL; Gubernator, K; Gutknecht, EM; Hubschwerlen, C; Kania, M; Oefner, C; Page, MG; Sogabe, S; Specklin, JL; Winkler, F Structure-based design of beta-lactamase inhibitors. 1. Synthesis and evaluation of bridged monobactams. J Med Chem41:3961-71 (1998) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-lactamase |
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| Name: | Beta-lactamase |
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| Synonyms: | AMPC_ECOLI | Beta-lactamase | Beta-lactamase (AmpC) | Beta-lactamase AmpC | Cephalosporinase | Escherichia coli K-12 | ampA | ampC |
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| Type: | Protien |
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| Mol. Mass.: | 41561.62 |
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| Organism: | Escherichia coli |
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| Description: | P00811 |
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| Residue: | 377 |
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| Sequence: | MFKTTLCALLITASCSTFAAPQQINDIVHRTITPLIEQQKIPGMAVAVIYQGKPYYFTWG
YADIAKKQPVTQQTLFELGSVSKTFTGVLGGDAIARGEIKLSDPTTKYWPELTAKQWNGI
TLLHLATYTAGGLPLQVPDEVKSSSDLLRFYQNWQPAWAPGTQRLYANSSIGLFGALAVK
PSGLSFEQAMQTRVFQPLKLNHTWINVPPAEEKNYAWGYREGKAVHVSPGALDAEAYGVK
STIEDMARWVQSNLKPLDINEKTLQQGIQLAQSRYWQTGDMYQGLGWEMLDWPVNPDSII
NGSDNKIALAARPVKAITPPTPAVRASWVHKTGATGGFGSYVAFIPEKELGIVMLANKNY
PNPARVDAAWQILNALQ
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| BDBM50067052 |
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| n/a |
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| Name | BDBM50067052 |
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| Synonyms: | CHEMBL129226 | Sodium; (1S,5R)-2-[2-(1-methyl-1H-imidazol-2-ylsulfanyl)-acetyl]-7-oxo-2,6-diaza-bicyclo[3.2.0]heptane-6-sulfonate |
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| Type | Small organic molecule |
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| Emp. Form. | C11H13N4O5S2 |
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| Mol. Mass. | 345.375 |
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| SMILES | Cn1ccnc1SCC(=O)N1CC[C@@H]2[C@H]1C(=O)N2S([O-])(=O)=O |
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| Structure | 
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