| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-lactamase |
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| Ligand | BDBM50067058 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_41020 (CHEMBL884132) |
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| IC50 | 24±n/a nM |
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| Citation |  Heinze-Krauss, I; Angehrn, P; Charnas, RL; Gubernator, K; Gutknecht, EM; Hubschwerlen, C; Kania, M; Oefner, C; Page, MG; Sogabe, S; Specklin, JL; Winkler, F Structure-based design of beta-lactamase inhibitors. 1. Synthesis and evaluation of bridged monobactams. J Med Chem41:3961-71 (1998) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-lactamase |
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| Name: | Beta-lactamase |
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| Synonyms: | AMPC_PSEAE | ampC | beta-Lactamase |
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| Type: | Enzyme |
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| Mol. Mass.: | 43406.87 |
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| Organism: | Pseudomonas aeruginosa (PAO1) |
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| Description: | P24735 |
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| Residue: | 397 |
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| Sequence: | MRDTRFPCLCGIAASTLLFATTPAIAGEAPADRLKALVDAAVQPVMKANDIPGLAVAISL
KGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALTQDKMRLDDRASQHWP
ALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNP
SIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVG
PGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEA
YDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRD
LGLVILANRNYPNAERVKIAYAILSGLEQQGKVPLKR
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| BDBM50067058 |
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| n/a |
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| Name | BDBM50067058 |
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| Synonyms: | CHEMBL338157 | Sodium; (1S,5R)-2-(3-carbamoyl-phenylcarbamoyl)-7-oxo-2,6-diaza-bicyclo[3.2.0]heptane-6-sulfonate |
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| Type | Small organic molecule |
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| Emp. Form. | C13H13N4O6S |
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| Mol. Mass. | 353.331 |
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| SMILES | NC(=O)c1cccc(NC(=O)N2CC[C@@H]3[C@H]2C(=O)N3S([O-])(=O)=O)c1 |
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| Structure | 
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