| Reaction Details |
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 | Report a problem with these data |
| Target | Urea transporter 1 |
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| Ligand | BDBM50512250 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1848172 (CHEMBL4348713) |
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| IC50 | 1300±n/a nM |
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| Citation |  Zhao, Y; Li, M; Li, B; Zhang, S; Su, A; Xing, Y; Ge, Z; Li, R; Yang, B Discovery and optimization of thienopyridine derivatives as novel urea transporter inhibitors. Eur J Med Chem172:131-142 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Urea transporter 1 |
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| Name: | Urea transporter 1 |
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| Synonyms: | Slc14a1 | UT11 | UT1_RAT | UT3 | Urea transporter B (UT-B) |
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| Type: | Protein |
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| Mol. Mass.: | 42037.85 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | n/a |
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| Residue: | 384 |
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| Sequence: | MEDIPTMVKVDRGESQILSCRGRRCGLKVLGYVTGDMKEFANWLKDKPVVLQFMDWILRG
ISQVVFVSNPISGILILAGLLVQNPWWALCGCVGTVVSTLTALLLSQDRSAIAAGLQGYN
ATLVGILMAVFSDKGDYFWWLIFPVSAMSMTCPVFSSALSSLFSKWDLPVFTLPFNMALS
LYLSATGHYNTFFPSKLFMPVSSVPNITWSELSALELLKSLPVGVGQIYGCDNPWTGAIF
LCAILLSSPLMCLHAAIGSLLGVIAGLSLAAPFKDIYSGLWGFNSSLACIAIGGMFMALT
WQTHLLALACALFTAYFGACMTHLMAAVHLPACTWSFCLATLLFLLLTTENPNIYRMPLS
KVTYSEENRIFYLQNKKRVVDSPL
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| BDBM50512250 |
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| n/a |
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| Name | BDBM50512250 |
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| Synonyms: | CHEMBL4464293 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H10N2O2S |
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| Mol. Mass. | 222.264 |
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| SMILES | COC(=O)c1sc2nc(C)ccc2c1N |
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| Structure | 
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