| Reaction Details |
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 | Report a problem with these data |
| Target | D-3-phosphoglycerate dehydrogenase |
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| Ligand | BDBM50512587 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1849693 (CHEMBL4350234) |
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| IC50 | 34±n/a nM |
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| Citation |  Mullarky, E; Xu, J; Robin, AD; Huggins, DJ; Jennings, A; Noguchi, N; Olland, A; Lakshminarasimhan, D; Miller, M; Tomita, D; Michino, M; Su, T; Zhang, G; Stamford, AW; Meinke, PT; Kargman, S; Cantley, LC Inhibition of 3-phosphoglycerate dehydrogenase (PHGDH) by indole amides abrogates de novo serine synthesis in cancer cells. Bioorg Med Chem Lett29:2503-2510 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| D-3-phosphoglycerate dehydrogenase |
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| Name: | D-3-phosphoglycerate dehydrogenase |
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| Synonyms: | D-3-phosphoglycerate dehydrogenase | PGDH3 | PHGDH | Phosphoglycerate dehydrogenase (PHGDH) | SERA_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 56650.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 533 |
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| Sequence: | MAFANLRKVLISDSLDPCCRKILQDGGLQVVEKQNLSKEELIAELQDCEGLIVRSATKVT
ADVINAAEKLQVVGRAGTGVDNVDLEAATRKGILVMNTPNGNSLSAAELTCGMIMCLARQ
IPQATASMKDGKWERKKFMGTELNGKTLGILGLGRIGREVATRMQSFGMKTIGYDPIISP
EVSASFGVQQLPLEEIWPLCDFITVHTPLLPSTTGLLNDNTFAQCKKGVRVVNCARGGIV
DEGALLRALQSGQCAGAALDVFTEEPPRDRALVDHENVISCPHLGASTKEAQSRCGEEIA
VQFVDMVKGKSLTGVVNAQALTSAFSPHTKPWIGLAEALGTLMRAWAGSPKGTIQVITQG
TSLKNAGNCLSPAVIVGLLKEASKQADVNLVNAKLLVKEAGLNVTTSHSPAAPGEQGFGE
CLLAVALAGAPYQAVGLVQGTTPVLQGLNGAVFRPEVPLRRDLPLLLFRTQTSDPAMLPT
MIGLLAEAGVRLLSYQTSLVSDGETWHVMGISSLLPSLEAWKQHVTEAFQFHF
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| BDBM50512587 |
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| n/a |
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| Name | BDBM50512587 |
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| Synonyms: | CHEMBL4452531 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H17Cl2FN2O4 |
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| Mol. Mass. | 451.275 |
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| SMILES | Cn1c(cc2c(Cl)c(Cl)ccc12)C(=O)NC1(COC1)c1ccc(CC(O)=O)c(F)c1 |
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| Structure | 
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