| Reaction Details |
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 | Report a problem with these data |
| Target | Receptor-interacting serine/threonine-protein kinase 1 |
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| Ligand | BDBM50513015 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1851532 (CHEMBL4352156) |
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| IC50 | 0.500000±n/a nM |
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| Citation |  Harris, PA; Faucher, N; George, N; Eidam, PM; King, BW; White, GV; Anderson, NA; Bandyopadhyay, D; Beal, AM; Beneton, V; Berger, SB; Campobasso, N; Campos, S; Capriotti, CA; Cox, JA; Daugan, A; Donche, F; Fouchet, MH; Finger, JN; Geddes, B; Gough, PJ; Grondin, P; Hoffman, BL; Hoffman, SJ; Hutchinson, SE; Jeong, JU; Jigorel, E; Lamoureux, P; Leister, LK; Lich, JD; Mahajan, MK; Meslamani, J; Mosley, JE; Nagilla, R; Nassau, PM; Ng, SL; Ouellette, MT; Pasikanti, KK; Potvain, F; Reilly, MA; Rivera, EJ; Sautet, S; Schaeffer, MC; Sehon, CA; Sun, H; Thorpe, JH; Totoritis, RD; Ward, P; Wellaway, N; Wisnoski, DD; Woolven, JM; Bertin, J; Marquis, RW Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase. J Med Chem62:5096-5110 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Receptor-interacting serine/threonine-protein kinase 1 |
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| Name: | Receptor-interacting serine/threonine-protein kinase 1 |
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| Synonyms: | Cell death protein RIP | RIP | RIP-1 | RIP1 | RIPK1 | RIPK1_HUMAN | Receptor-interacting protein 1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 75926.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13546 |
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| Residue: | 671 |
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| Sequence: | MQPDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEAL
LEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIIL
EIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVD
GTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMC
IKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEED
VKSLKKEYSNENAVVKRMQSLQLDCVAVPSSRSNSATEQPGSLHSSQGLGMGPVEESWFA
PSLEHPQEENEPSLQSKLQDEANYHLYGSRMDRQTKQQPRQNVAYNREEERRRRVSHDPF
AQQRPYENFQNTEGKGTAYSSAASHGNAVHQPSGLTSQPQVLYQNNGLYSSHGFGTRPLD
PGTAGPRVWYRPIPSHMPSLHNIPVPETNYLGNTPTMPFSSLPPTDESIKYTIYNSTGIQ
IGAYNYMEIGGTSSSLLDSTNTNFKEEPAAKYQAIFDNTTSLTDKHLDPIRENLGKHWKN
CARKLGFTQSQIDEIDHDYERDGLKEKVYQMLQKWVMREGIKGATVGKLAQALHQCSRID
LLSSLIYVSQN
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| BDBM50513015 |
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| n/a |
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| Name | BDBM50513015 |
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| Synonyms: | CHEMBL4537171 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H17FN2O |
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| Mol. Mass. | 248.296 |
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| SMILES | CC(C)(C)C(=O)N1N=CCC1c1cccc(F)c1 |c:7| |
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| Structure | 
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