| Reaction Details |
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 | Report a problem with these data |
| Target | Lysine-specific demethylase 4B |
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| Ligand | BDBM50513360 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1853065 (CHEMBL4353689) |
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| IC50 | 29±n/a nM |
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| Citation |  Le Bihan, YV; Lanigan, RM; Atrash, B; McLaughlin, MG; Velupillai, S; Malcolm, AG; England, KS; Ruda, GF; Mok, NY; Tumber, A; Tomlin, K; Saville, H; Shehu, E; McAndrew, C; Carmichael, L; Bennett, JM; Jeganathan, F; Eve, P; Donovan, A; Hayes, A; Wood, F; Raynaud, FI; Fedorov, O; Brennan, PE; Burke, R; van Montfort, RLM; Rossanese, OW; Blagg, J; Bavetsias, V C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays. Eur J Med Chem177:316-337 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysine-specific demethylase 4B |
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| Name: | Lysine-specific demethylase 4B |
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| Synonyms: | JHDM3B | JMJD2B | JmjC domain-containing histone demethylation protein 3B | Jumonji domain-containing protein 2B | KDM4B | KDM4B_HUMAN | KIAA0876 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 121904.33 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_109446 |
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| Residue: | 1096 |
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| Sequence: | MGSEDHGAQNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPRQTY
DDIDDVVIPAPIQQVVTGQSGLFTQYNIQKKAMTVGEYRRLANSEKYCTPRHQDFDDLER
KYWKNLTFVSPIYGADISGSLYDDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYLYFG
MWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDAFLR
HKMTLISPIILKKYGIPFSRITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATLRWIDY
GKVATQCTCRKDMVKISMDVFVRILQPERYELWKQGKDLTVLDHTRPTALTSPELSSWSA
SRASLKAKLLRRSHRKRSQPKKPKPEDPKFPGEGTAGAALLEEAGGSVKEEAGPEVDPEE
EEEEPQPLPHGREAEGAEEDGRGKLRPTKAKSERKKKSFGLLPPQLPPPPAHFPSEEALW
LPSPLEPPVLGPGPAAMEESPLPAPLNVVPPEVPSEELEAKPRPIIPMLYVVPRPGKAAF
NQEHVSCQQAFEHFAQKGPTWKEPVSPMELTGPEDGAASSGAGRMETKARAGEGQAPSTF
SKLKMEIKKSRRHPLGRPPTRSPLSVVKQEASSDEEASPFSGEEDVSDPDALRPLLSLQW
KNRAASFQAERKFNAAAARTEPYCAICTLFYPYCQALQTEKEAPIASLGKGCPATLPSKS
RQKTRPLIPEMCFTSGGENTEPLPANSYIGDDGTSPLIACGKCCLQVHASCYGIRPELVN
EGWTCSRCAAHAWTAECCLCNLRGGALQMTTDRRWIHVICAIAVPEARFLNVIERHPVDI
SAIPEQRWKLKCVYCRKRMKKVSGACIQCSYEHCSTSFHVTCAHAAGVLMEPDDWPYVVS
ITCLKHKSGGHAVQLLRAVSLGQVVITKNRNGLYYRCRVIGAASQTCYEVNFDDGSYSDN
LYPESITSRDCVQLGPPSEGELVELRWTDGNLYKAKFISSVTSHIYQVEFEDGSQLTVKR
GDIFTLEEELPKRVRSRLSLSTGAPQEPAFSGEEAKAAKRPRVGTPLATEDSGRSQDYVA
FVESLLQVQGRPGAPF
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| BDBM50513360 |
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| n/a |
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| Name | BDBM50513360 |
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| Synonyms: | CHEMBL4573390 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H25ClN6O |
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| Mol. Mass. | 448.948 |
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| SMILES | CC1(CCN(CCc2cnn(c2)-c2nccc3c2nc[nH]c3=O)CC1)c1cccc(Cl)c1 |
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| Structure | 
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