| Reaction Details |
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 | Report a problem with these data |
| Target | Cysteinyl leukotriene receptor 1/2 |
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| Ligand | BDBM50069350 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_99857 (CHEMBL706927) |
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| IC50 | 0.350000±n/a nM |
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| Citation |  Guay, D; Gauthier, JY; Dufresne, C; Jones, TR; McAuliffe, M; McFarlane, C; Metters, KM; Prasit, P; Rochette, C; Roy, P; Sawyer, N; Zamboni, R A series of non-quinoline cysLT1 receptor antagonists: SAR study on pyridyl analogs of Singulair. Bioorg Med Chem Lett8:453-8 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Cysteinyl leukotriene receptor 1/2 |
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| Name: | Cysteinyl leukotriene receptor 1/2 |
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| Synonyms: | Cysteinyl leukotriene receptor |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 98640 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Cysteinyl leukotriene receptor 1 |
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| Synonyms: | CLTR1_HUMAN | CYSLT1 | CYSLTR1 | Cysteinyl leukotriene D4 receptor | Cysteinyl leukotriene receptor | Cysteinyl leukotriene receptor 1 | HG55 | HMTMF81 | LTD4 receptor | Leukotriene Cysteinyl 1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 38565.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Leukotriene Cysteinyl 1 CYSLTR1 HUMAN::Q9Y271 |
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| Residue: | 337 |
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| Sequence: | MDETGNLTVSSATCHDTIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQV
YMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFF
RCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDN
QTKNHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSHKKAIGMIMVVTA
AFLVSFMPYHIQRTIHLHFLHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGG
NFRKRLSTFRKHSLSSVTYVPRKKASLPEKGEEICKV
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| Component 2 |
| Name: | Cysteinyl leukotriene receptor 2 |
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| Synonyms: | CLTR2_HUMAN | CYSLT2 | CYSLT2R | CYSLTR2 | Cysteinyl leukotriene receptor | Cysteinyl leukotriene receptor 2 | Leukotriene Cysteinyl 2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 39657.52 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Leukotriene Cysteinyl 2 CYSLTR2 HUMAN::Q9NS75 |
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| Residue: | 346 |
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| Sequence: | MERKFMSLQPSISVSEMEPNGTFSNNNSRNCTIENFKREFFPIVYLIIFFWGVLGNGLSI
YVFLQPYKKSTSVNVFMLNLAISDLLFISTLPFRADYYLRGSNWIFGDLACRIMSYSLYV
NMYSSIYFLTVLSVVRFLAMVHPFRLLHVTSIRSAWILCGIIWILIMASSIMLLDSGSEQ
NGSVTSCLELNLYKIAKLQTMNYIALVVGCLLPFFTLSICYLLIIRVLLKVEVPESGLRV
SHRKALTTIIITLIIFFLCFLPYHTLRTVHLTTWKVGLCKDRLHKALVITLALAAANACF
NPLLYYFAGENFKDRLKSALRKGHPQKAKTKCVFPVSVWLRKETRV
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| BDBM50069350 |
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| n/a |
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| Name | BDBM50069350 |
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| Synonyms: | (1-{(R)-1-{3-[(E)-2-(7,7-Dimethyl-6,7-dihydro-5H-[1]pyrindin-2-yl)-vinyl]-phenyl}-3-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-propylsulfanylmethyl}-cyclopropyl)-acetic acid | CHEMBL140381 |
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| Type | Small organic molecule |
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| Emp. Form. | C36H43NO3S |
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| Mol. Mass. | 569.797 |
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| SMILES | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(O)=O)CC1)c1cccc(\C=C\c2ccc3CCC(C)(C)c3n2)c1 |
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| Structure | 
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