| Reaction Details |
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 | Report a problem with these data |
| Target | Induced myeloid leukemia cell differentiation protein Mcl-1 |
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| Ligand | BDBM50514220 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1855858 (CHEMBL4356587) |
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| Ki | 0.040000±n/a nM |
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| Citation |  Rescourio, G; Gonzalez, AZ; Jabri, S; Belmontes, B; Moody, G; Whittington, D; Huang, X; Caenepeel, S; Cardozo, M; Cheng, AC; Chow, D; Dou, H; Jones, A; Kelly, RC; Li, Y; Lizarzaburu, M; Lo, MC; Mallari, R; Meleza, C; Rew, Y; Simonovich, S; Sun, D; Turcotte, S; Yan, X; Wong, SG; Yanez, E; Zancanella, M; Houze, J; Medina, JC; Hughes, PE; Brown, SP Discovery and in Vivo Evaluation of Macrocyclic Mcl-1 Inhibitors Featuring an ?-Hydroxy Phenylacetic Acid Pharmacophore or Bioisostere. J Med Chem62:10258-10271 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Induced myeloid leukemia cell differentiation protein Mcl-1 |
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| Name: | Induced myeloid leukemia cell differentiation protein Mcl-1 |
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| Synonyms: | BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT |
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| Type: | Membrane; Single-pass membrane protein |
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| Mol. Mass.: | 37332.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q07820 |
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| Residue: | 350 |
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| Sequence: | MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGS
AGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIM
SPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLE
IISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNE
DDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVR
TKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
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| BDBM50514220 |
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| n/a |
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| Name | BDBM50514220 |
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| Synonyms: | CHEMBL4535151 | US11274105, Example 188 |
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| Type | Small organic molecule |
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| Emp. Form. | C39H52ClN5O8S |
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| Mol. Mass. | 786.377 |
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| SMILES | [H][C@@]12CC[C@@]1([H])[C@@H](OCC(=O)N(C)C)\C=C\CCN(C)C(=O)C[C@](O)(C(=O)NS(=O)(=O)N(C)C)c1ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C2)c3c1 |r,t:15| |
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| Structure | 
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