| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sphingosine kinase 2 |
|---|
| Ligand | BDBM50514474 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1856910 (CHEMBL4357639) |
|---|
| Ki | 201±n/a nM |
|---|
| Citation |  Sibley, CD; Morris, EA; Kharel, Y; Brown, AM; Huang, T; Bevan, DR; Lynch, KR; Santos, WL Discovery of a Small Side Cavity in Sphingosine Kinase 2 that Enhances Inhibitor Potency and Selectivity. J Med Chem63:1178-1198 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sphingosine kinase 2 |
|---|
| Name: | Sphingosine kinase 2 |
|---|
| Synonyms: | SK 2 | SK2 | SPHK2 | SPHK2_HUMAN | SPK 2 | Sphingosine kinase 2 | Sphingosine kinase types 2 (SphK2) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 69221.44 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9NRA0 |
|---|
| Residue: | 654 |
|---|
| Sequence: | MNGHLEAEEQQDQRPDQELTGSWGHGPRSTLVRAKAMAPPPPPLAASTPLLHGEFGSYPA
RGPRFALTLTSQALHIQRLRPKPEARPRGGLVPLAEVSGCCTLRSRSPSDSAAYFCIYTY
PRGRRGARRRATRTFRADGAATYEENRAEAQRWATALTCLLRGLPLPGDGEITPDLLPRP
PRLLLLVNPFGGRGLAWQWCKNHVLPMISEAGLSFNLIQTERQNHARELVQGLSLSEWDG
IVTVSGDGLLHEVLNGLLDRPDWEEAVKMPVGILPCGSGNALAGAVNQHGGFEPALGLDL
LLNCSLLLCRGGGHPLDLLSVTLASGSRCFSFLSVAWGFVSDVDIQSERFRALGSARFTL
GTVLGLATLHTYRGRLSYLPATVEPASPTPAHSLPRAKSELTLTPDPAPPMAHSPLHRSV
SDLPLPLPQPALASPGSPEPLPILSLNGGGPELAGDWGGAGDAPLSPDPLLSSPPGSPKA
ALHSPVSEGAPVIPPSSGLPLPTPDARVGASTCGPPDHLLPPLGTPLPPDWVTLEGDFVL
MLAISPSHLGADLVAAPHARFDDGLVHLCWVRSGISRAALLRLFLAMERGSHFSLGCPQL
GYAAARAFRLEPLTPRGVLTVDGEQVEYGPLQAQMHPGIGTLLTGPPGCPGREP
|
|
|
|---|
| BDBM50514474 |
|---|
| n/a |
|---|
| Name | BDBM50514474 |
|---|
| Synonyms: | CHEMBL4462152 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H27ClF3N5O2 |
|---|
| Mol. Mass. | 509.952 |
|---|
| SMILES | Cl.CCCc1cc(ccc1OCc1ccc(cc1)C(F)(F)F)-c1noc(n1)[C@@H]1CCCN1C(N)=N |r| |
|---|
| Structure | 
|
|---|
Search and Browse
